食品科学

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多不饱和脂肪酸对神经细胞保护作用的研究进展

刘志国,王华林,王丽梅,刘烈炬*   

  1. 武汉轻工大学生物与制药工程学院,湖北 武汉 430023
  • 出版日期:2016-04-15 发布日期:2016-04-13

Advances in Research on Neuron-Protective Role of Polyunsaturated Fatty Acids

LIU Zhiguo, WANG Hualin, WANG Limei, LIU Lieju*   

  1. School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China
  • Online:2016-04-15 Published:2016-04-13

摘要:

本文从细胞生物学的角度综述多不饱和脂肪酸(polyunsaturated fatty acids,PUFAs)改善大脑功能的作用机理,包括PUFAs促进神经细胞生成(neurogenesis)、维持神经细胞形态和功能、促进神经突生长、防止神经细胞变性(neurodegeneration)、抑制神经细胞凋亡(apoptosis),以及调节神经细胞膜流动性和可塑性(plasticity)、端粒(telomere)活性等作用机制,为PUFAs的营养干预研究应用,特别是应用于保护大脑正常功能,防止生理性衰老和疾病性脑功能障碍(如阿尔兹海默氏症和帕金森症)所致的脑功能障碍提供参考。

关键词: 多不饱和脂肪酸, 神经变性, 神经细胞, 神经发生, 大脑功能

Abstract:

The protective effects of polyunsaturated fatty acids (PUFAs) on brain function and the nervous system have
attracted a lot of attention. Numerous studies have illustrated the anti-inflammation, anti-oxidative and cardiovascular
protective effects of PUFAs, as well as the protective effects on brain function, particularly nerve cells. In this article,
we review the mechanisms of brain-protective effects of PUFAs in following fields: how PUFAs promote neurogenesis,
maintain nerve cell morphology and function, improve neurite growth; prevent neurodegeneration, depress nerve cell
apoptosis and regulate membrane fluidity, plasticity and telomere activity in neurons. This review provides a prospective
insight on nutritional studies of PUFAs against aging and/or diseases (such as Alzheimer’s disease and Parkinson’s disease)
inducing brain disorders.

Key words: polyunsaturated fatty acid, neurodegeneration, nerve cells, neurogenesis, brain function

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