食品科学

• 营养卫生 • 上一篇    下一篇

叶黄素对母鼠乳腺分泌IgA的促进作用

崔焕忠,张 辉,杨雨江,尹 剑,兰海楠,郑 鑫*   

  1. 吉林农业大学动物科学技术学院,吉林 长春 130118
  • 出版日期:2016-06-15 发布日期:2016-06-27

Promoting Effect of Lutein on the IgA Secretion Capacity of Mammary Glands in Maternal Mice

CUI Huanzhong, ZHANG Hui, YANG Yujiang, YIN Jian, LAN Hainan, ZHENG Xin*   

  1. College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China
  • Online:2016-06-15 Published:2016-06-27

摘要:

为明确叶黄素对母鼠乳腺分泌IgA能力的影响,本实验对妊娠母鼠添加饲喂叶黄素,检测母鼠血清中IgG、IgA和IgM含量变化,母鼠乳腺组织中IgA mRNA表达量和IgA抗体分泌细胞数量变化,以及仔鼠胃内容物中IgA浓度变化。结果表明:在妊娠21 d和分娩后7 d时,实验组血清中IgG和IgA浓度显著高于正常对照组(P<0.05),IgM含量虽有升高,与正常对照组相比,无显著性差异(P>0.05);乳腺组织中IgA mRNA表达量无显著变化(P>0.05);分娩后14 d IgA抗体分泌细胞数量显著增加(P<0.05);仔鼠胃内容物中IgA含量极显著高于对照组(P<0.01)。说明给妊娠母鼠添加饲喂叶黄素可以增强乳腺分泌IgA的能力。

关键词: 母鼠, 叶黄素, 乳腺, IgA

Abstract:

The present experiment was conducted to explore the effect of supplemental lutein on the serum concentrations of
IgG, IgA and IgM, the mRNA expression of IgA C-region and the number of IgA antibody-secreting cells (ASC) in breast
of maternal mice as well as IgA concentration in stomach contents of neonatal mice. Maternal mice were fed rodent feed or
50 mg/kg lutein-supplemented rodent feed during pregnancy and after parturition. The serum concentrations of IgG and
IgA increased significantly at 21 days of pregnancy and at 7 days after parturition (P < 0.05), but IgM concentration and the
mRNA expression of IgA C-region were not significantly affected by lutein supplementation (P > 0.05). The number
of IgA ASC at 14 days after parturition (P < 0.05) and the IgA concentration in stomach contents of neonatal mice at 7 and
14 days after parturition were enhanced markedly (P < 0.01) in response to lutein supplemention. These results indicated that
supplemental lutein for maternal mice is effective in enhancing the secretion of IgA in mammary glands.

Key words: maternal mouse, lutein, mammary glands, IgA

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