蓝莓叶多酚对高脂小鼠血脂及肝脏组织的影响

doi:10.7506/spkx1002-6630-201611039

摘要/Abstract

摘要：

目的：通过给小鼠灌胃不同剂量的蓝莓叶多酚，研究蓝莓叶多酚对小鼠血脂及肝脏组织的影响。方法：60 只健康昆明小鼠随机分为6 组，基础组、高脂模型组、蓝莓叶多酚低剂量组（50 mg/（kg·d））、蓝莓叶多酚中剂量组（150 mg/（kg·d））、蓝莓叶多酚高剂量组（300 mg/（kg·d））、立普妥阳性对照组（3 mg/（kg·d）），连续灌胃30 d，眼球取血，取出肝脏，测定血脂及肝脏指标。结果：灌胃50 mg/（kg·d）的蓝莓叶多酚，小鼠血清总胆固醇（total cholesterol，TC）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL-C）水平较高脂模型组显著降低（P＜0.05），且肝脏中谷草转氨酶（glutamic oxalacetic transaminase，AST）活力较高脂模型组的（329.57±15.06） U/g pro下降了26.7%；当蓝莓叶多酚的剂量增加至150 mg/（kg·d）时，小鼠血清总胆固醇、甘油三酯（triglyceride，TG）、LDL-C水平显著低于高脂模型组（P＜0.05），高密度脂蛋白胆固醇水平（high densitylipoprotein cholesterol，HDL-C）显著高于高脂模型组（P＜0.05），且肝脏中谷草转氨酶的含量较高脂模型组显著降低（P＜0.05）；当蓝莓叶多酚的剂量增加至300 mg/（kg·d）时，小鼠血清总胆固醇、甘油三酯及低密度脂蛋白胆固醇水平较高脂模型组显著降低（P＜0.05），高密度脂蛋白胆固醇水平较高脂模型组显著升高（P＜0.05），且肝脏指数由高脂模型组的（4.98±0.33）%降至（4.19±0.14）%，肝脏中的谷草转氨酶及谷丙转氨酶（alaninetransaminase，ALT）的活力分别比高脂模型组的（329.57±15.06）、（354.31±23.31） U/g pro下降了32.15%和22.96%。结论：实验结果表明蓝莓叶多酚具有调节血脂及保护肝脏的功效。

关键词: 蓝莓叶多酚, 血脂, 肝脏

Abstract:

Purpose: To explore the effect of blueberry leaf polyphenols (BLP) at different doses on blood lipids and
liver parameters in mice. Methods: Totally 60 healthy mice were randomly divided into 6 groups, including basic group,
hyperlipidemic model group, BLP low, middle and high dose groups (at 50, 150 and 300 mg/(kg·d), respectively), and positive
control group (lipitor at 3 mg/(kg·d)). The administration lasted for 30 days, and then blood samples were harvested from the
eyeballs, and the mice were sacrificed for the collection of liver tissues. The serum lipids and liver indexes were determined.
Results: The mice administered with BLP at 50 mg/(kg·d) revealed significant decreases in serum TC and LDL-C levels
compared with the model mice (P < 0.05); meanwhile, the activity of glutamic oxalacetic transaminase (AST) in liver was
lower by 26.7% than that ((329.57 ± 15.06) U/g pro) of the model mice. When the dose was increased to 150 mg/(kg·d), the
levels of TC, TG and LDL-C in serum as well as AST activity in liver were significantly decreased when compared with those
in the model group (P < 0.05); in contrast, HDL-C was significantly higher than that in the model group (P < 0.05). When
the dose was further increased to 300 mg/(kg·d), serum TC, TG and LDL-C were reduced significantly (P < 0.05), but serum
HDL-C was increased in comparison with the model group (P < 0.05); the liver index was (4.19 ± 0.14)%, lower than that
((4.98 ± 0.33)%) of the model group, and the activities of AST and alanine transaminase (ALT) in live declined
by 32.15% and 22.96% when compared with those in the model group, which were (329.57 ± 15.06) U/g pro and
(354.31 ± 23.31) U/g pro), respectively. Conclusion: Blueberry leaf polyphenols have the potential for regulating blood
lipids and protecting the liver.

Key words: blueberry leaf polyphenols, blood lipid, liver

中图分类号:

TS201.4

华雨薇，李春阳，王帆，刘晓林. 蓝莓叶多酚对高脂小鼠血脂及肝脏组织的影响[J]. 食品科学, doi: 10.7506/spkx1002-6630-201611039.

HUA Yuwei, LI Chunyang, WANG Fan, LIU Xiaolin. Effect of Blueberry Leaf Polyphenols on Blood Lipids and Liver Parameters in Hyperlipidemic Mice[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201611039.

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蓝莓叶多酚对高脂小鼠血脂及肝脏组织的影响

Effect of Blueberry Leaf Polyphenols on Blood Lipids and Liver Parameters in Hyperlipidemic Mice

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