食品科学

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LuxS/AI-2型群体感应系统调控细菌生物被膜形成研究进展

刘 蕾1,桂 萌2,武瑞赟1,3,李平兰1,*   

  1. 1.中国农业大学食品科学与营养工程学院,北京食品营养与人类健康高精尖创新中心,北京 100083;
    2.北京市水产科学研究所,北京 100068;3.内蒙古大学生命科学学院,内蒙古 呼和浩特 010021
  • 出版日期:2016-10-15 发布日期:2016-12-01

Progress in Research on Biofilm Formation Regulated by LuxS/AI-2 Quorum Sensing

LIU Lei1, GUI Meng2, WU Ruiyun1,3, LI Pinglan1,*   

  1. 1. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; 2. Beijing Fisheries Research Institute, Beijing 100068, China; 3. College of Life Sciences, Inner Mongolia University, Hohhot 010021, China
  • Online:2016-10-15 Published:2016-12-01

摘要:

生物被膜是大多数细菌在自然状态下的一种生长方式,使菌体具有浮游态时不具有的优势。它的形成和发展受到群体感应系统的调控,该系统是细菌依赖于群体密度而调控其生理行为的一种机制。其中LuxS/2型自诱导物(autoinducer 2,AI-2)群体感应系统又称种间群体感应系统,广泛存在于G+及G-菌中。其信号分子AI-2被认为是种间通用的信号分子,参与调控多种细菌的生物被膜。此外,目前已发现多种LuxS/AI-2型群体感应系统抑制剂,它们可以影响许多细菌生物被膜的形成。目前研究人员已开始致力于揭示LuxS/AI-2型群体感应系统调控生物被膜形成的分子机制,这对于进一步理解LuxS/AI-2型群体感应系统与生物被膜的关系具有重要意义。

关键词: 生物被膜, LuxS/AI-2型群体感应系统, 2型自诱导物, 群体感应抑制剂, 调控机制

Abstract:

The majority of bacteria form biofilms for growth and development and bacteria within biofilms may better adapt
to environment than their planktonic counterparts. LuxS-dependent quorum sensing is a widespread system used by bacteria
for cell-to-cell communication, which can regulate biofilm formation in a cell density-dependent manner. Autoinducer 2 (AI-2)
produced by LuxS, is a species-nonspecific signal used by both gram-negative and gram-positive bacteria for biofilm
formation. Currently, several inhibitors of LuxS/AI-2 quorum sensing have been determined to influence biofilm formation
based on their anti-AI-2 communication mechanisms. Recently, there has been a surging interest in the mechanism of biofilm
regulation by LuxS/AI-2 quorum sensing system, which is important to better understand the relationship between LuxSdependent
QS system and biofilm formation.

Key words: biofilms, LuxS/AI-2 quorum sensing, autoinducer 2, quorum sensing inhibitor, regulation mechanism

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