玉米油与猪油1∶1调和油对小鼠血脂、肝功能及肝脏抗氧化能力的影响

doi:10.7506/spkx1002-6630-201705042

食品科学

玉米油与猪油1∶1调和油对小鼠血脂、肝功能及肝脏抗氧化能力的影响

王吉1,2，严思思1,2，谢文1,2，周慧娟1,2，黄海滨1,2，刘必英1,2，冯春红1，文利新1,2,*

1.湖南农业大学动物医学院，湖南长沙 410128；2.湖南畜禽安全生产协同创新中心，湖南长沙 410128

出版日期:2017-03-15 发布日期:2017-03-28

Effect of Dietary Blend of Corn Oil and Lard at a Ratio of 1:1 on Blood Lipid, Liver Function and Liver Antioxidant Capacity in Mice

WANG Ji1,2, YAN Sisi1,2, XIE Wen1,2, ZHOU Huijuan1,2, HUANG Haibin1,2, LIU Biying1,2, FENG Chunhong1, WEN Lixin1,2,*

1. College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China; 2. Hunan Synthetic Innovation Center for Livestock Production Safety, Changsha 410128, China

Online:2017-03-15 Published:2017-03-28

摘要/Abstract

摘要： 目的：模拟中国人饮食习惯，以小鼠为实验对象，探讨不同玉米油与猪油1∶1调和油（后称为调和油）摄入量对其血脂含量、肝功能以及肝脏抗氧化能力的影响。方法：将24 只8 周龄雄性昆明小鼠随机平均分为空白组、推荐摄入量组和实际摄入量组，每组分别在基础日粮中添加0%、3.8%和6.5%（质量分数）的调和油，饲喂8 周后称小鼠体质量，解剖，取外周血清检测血脂和肝功能指标，取完整肝脏测量肝指数、进行组织形态观测和组织切片镜检，对肝脏进行组织匀浆检测氧化损伤指标。结果：小鼠的肝指数与饲料中所添加的调和油剂量呈正相关，空白组小鼠肝脏碱性磷酸酶、谷丙转氨酶和谷草转氨酶活性均明显高于摄入油脂组，推荐摄入量组的小鼠肝脏总抗氧化能力显著高于空白组和实际摄入量组，空白组的肝脏氧化损伤程度显著高于推荐摄入量组和实际摄入量组。结论：不食用油脂对小鼠肝功能有一定的影响；推荐摄入量的玉米油与猪油1∶1调和油能提高小鼠肝脏抗氧化能力，降低氧化损伤。

关键词: 玉米油, 猪油, 调和油, 血脂, 肝功能, 抗氧化

Abstract: Objective: To explore the effect of dietary blend of corn oil and lard at a ratio of 1:1 on blood lipid, liver function and liver antioxidant capacity in mice by simulating Chinese dietary habits. Methods: A total of 24 eight-week male SPF Kunming mice were randomly divided into blank, recommended intake and actual intake groups, which were fed a basal diet supplemented with 0%, 3.8%, and 6.5% of the oil blend, respectively. After 8 weeks, body weight was measured, and peripheral blood was collected for determining serum lipids and liver function indices. The intact liver tissue was collected for the calculation of liver index and morphological and histological examination under microscope. Moreover, liver homogenate was prepared for evaluation of oxidative stress. Results: The liver index in mice was positively correlated with the dietary amount of the oil bend. Alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) activities in mice from the blank group were significantly higher than those in mice from the recommended intake and actual intake groups. However, total antioxidant capacity in the liver of mice from the recommended intake group was significantly higher than in mice from the blank and actual intake groups. Oxidative liver injury in mice from the blank group was significantly greater than in mice from the two other groups. Conclusion: Insufficient dietary oil has a negative effect on liver function in mice. The recommended intake of corn oil/lard blend at 1:1 can enhance liver antioxidant capacity in mice and reduce oxidative damage.

Key words: corn oil, lard, oil blend, blood lipid, liver function, antioxidant

中图分类号:

S879.6

王吉，严思思，谢文，周慧娟，黄海滨，刘必英，冯春红，文利新. 玉米油与猪油1∶1调和油对小鼠血脂、肝功能及肝脏抗氧化能力的影响[J]. 食品科学, doi: 10.7506/spkx1002-6630-201705042.

WANG Ji, YAN Sisi, XIE Wen, ZHOU Huijuan, HUANG Haibin, LIU Biying, FENG Chunhong, WEN Lixin. Effect of Dietary Blend of Corn Oil and Lard at a Ratio of 1:1 on Blood Lipid, Liver Function and Liver Antioxidant Capacity in Mice[J]. FOOD SCIENCE, doi: 10.7506/spkx1002-6630-201705042.

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玉米油与猪油1∶1调和油对小鼠血脂、肝功能及肝脏抗氧化能力的影响

Effect of Dietary Blend of Corn Oil and Lard at a Ratio of 1:1 on Blood Lipid, Liver Function and Liver Antioxidant Capacity in Mice

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