3株益生菌体外降胆固醇能力及体内降血脂效果评价

doi:10.7506/spkx1002-6630-201723021

食品科学 ›› 2017, Vol. 38 ›› Issue (23): 129-134.doi: 10.7506/spkx1002-6630-201723021

3株益生菌体外降胆固醇能力及体内降血脂效果评价

韦云路，刘义，王瑶，孟祥飞，李平兰*

中国农业大学食品科学与营养工程学院，北京食品营养与人类健康高精尖创新中心，教育部-北京市共建功能乳品重点实验室，北京 100083

出版日期:2017-12-15 发布日期:2017-12-07
基金资助:
国家自然科学基金面上项目（31271827；31671831）

Cholesterol-Lowering Ability in Vitro and Hypolipidemic Effect in Vivo of Three Probiotic Strains

WEI Yunlu, LIU Yi, WANG Yao, MENG Xiangfei, LI Pinglan*

Key Laboratory of Functional Dairy, Co-Constructed by Ministry of Education and Beijing Government, Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China

Online:2017-12-15 Published:2017-12-07

摘要/Abstract

摘要： 为探讨动物双歧杆菌LPL-RH、长双歧杆菌TTF及植物乳杆菌LPL-1作为降血脂益生菌的潜力，测定 3 株益生菌的体外胆固醇脱除率和胆盐水解酶活力，同时以益生菌灌胃高脂饮食大鼠6 周后测定大鼠血脂含量变化。研究结果表明：菌株LPL-RH、TTF、LPL-1的体外胆固醇脱除率分别为23.8%、24.5%、20.9%，无显著差异（P＞0.05）；且3 株菌均有胆盐水解酶活性。菌株LPL-RH、TTF、LPL-1干预分别使高脂大鼠血清胆固醇含量分别降低17.3%、11.4%、10.1%；血清甘油三酯含量降低19.1%、16.8%、11.5%；血清低密度脂蛋白胆固醇含量降低 24.0%、20.0%、10.0%；血清高密度脂蛋白胆固醇含量升高10.3%、5.2%和1.7%。综合而言，3 株益生菌在体内对高脂饮食大鼠血脂有调节作用，均有开发为降血脂益生菌的潜力，其中动物双歧杆菌LPL-RH的体内降脂能力最为突出。

关键词: 益生菌, 降胆固醇, 降血脂

Abstract: This study aimed to investigate the hypolipidemic potential of Bifidobacterium animalis LPL-RH, B. longum TTF and Lactobacillus plantarum LPL-1. The cholesterol-lowering ability and bile salt hydrolase activity were determined. Then, the effect of probiotic intervention on blood lipids in high-fat diet fed SD rats was examined. The results showed that the cholesterol removal rates of B. animalis LPL-RH, B. longum TTF and L. plantarum LPL-1 were 23.8%, 24.5% and 20.9%, respectively, with no significant differences among them. All three probiotics had bile salt hydrolase activity. The assays in vivo showed that intervention with LPL-RH, TTF and LPL-1 decreased serum cholesterol by 17.3%, 11.4% and 10.1%, triglycerides by 19.1%, 16.8% and 11.5%, and low-density lipoprotein cholesterol by 24.0%, 20.0% and 10.0%, and increased high-density lipoprotein cholesterol by 10.3%, 5.2% and 1.7% in hyperlipidemia rats, respectively. In summary, the three strains have the potential to be developed as lipid-lowering probiotics, with B. animalis LPL-RH having the best lipid-lowering ability.

Key words: probiotics, cholesterol-lowering, hypolipidemic

中图分类号:

TS201.3

韦云路，刘义，王瑶，孟祥飞，李平兰. 3株益生菌体外降胆固醇能力及体内降血脂效果评价[J]. 食品科学, 2017, 38(23): 129-134.

WEI Yunlu, LIU Yi, WANG Yao, MENG Xiangfei, LI Pinglan. Cholesterol-Lowering Ability in Vitro and Hypolipidemic Effect in Vivo of Three Probiotic Strains[J]. FOOD SCIENCE, 2017, 38(23): 129-134.

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3株益生菌体外降胆固醇能力及体内降血脂效果评价

Cholesterol-Lowering Ability in Vitro and Hypolipidemic Effect in Vivo of Three Probiotic Strains

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