食品科学 ›› 2011, Vol. 32 ›› Issue (13): 332-335.doi: 10.7506/spkx1002-6630-201113072

• 营养卫生 • 上一篇    下一篇

油茶籽油对大鼠降血脂和预防脂肪肝的影响

黄翠莉,吴苏喜*,刘瑞兴,郝泽金   

  1. 长沙理工大学化学与生物工程学院
  • 出版日期:2011-07-15 发布日期:2011-07-02
  • 基金资助:
    湖南省科技计划项目(2010WK2004;2010CK3024);湖南省研究生科研创新项目(CX2009B184)

Blood Lipid-lowering and Fatty Liver-preventing Effects of Tea Seed (Camellia oleifera Abel.) Oil in Rats

HUANG Cui-li,WU Su-xi*,LIU Rui-xing,HAO Ze-jin   

  1. (College of Chemistry and Bio-engineering, Changsha University of Science & Technology, Changsha 410114, China)
  • Online:2011-07-15 Published:2011-07-02

摘要: 目的:考察油茶籽油辅助降血脂和预防脂肪肝的作用。方法:采用SD大鼠,预饲养4d后随机分成6组(每组10只):A.高脂对照组、B.空白对照组、C.高剂量茶籽油组、D.中剂量茶籽油组、E.低剂量茶籽油组、F.橄榄油对照组;各组每kg体质量的日喂食标准为:A. 150g高脂饲料和9.0g生理盐水,B. 150g基础饲料和9.0g生理盐水,C. 150g高脂饲料和9.0g油茶籽油,D. 150g高脂饲料和3.0g油茶籽油,E.150g高脂饲料和1.5g油茶籽油,F. 150g高脂饲料和9.0g橄榄油,并以高脂饲料建立高脂模型;连续饲养7周后杀鼠,制备血清以备测定其甘油三酯(TG)、总胆固醇(TC)和高密度脂蛋白胆固醇(HDL-C)含量,并取肝脏进行病理切片、观察其脂肪病变程度。结果:与高脂对照组比较,3个剂量茶籽油组大鼠血清的TG和TC水平均极显著地降低(P<0.01);3个剂量茶籽油组大鼠肝脏的脂肪病变程度明显轻于高脂对照组(P<0.05),其中,高剂量组与橄榄油组类似,即:90%病例为正常肝或轻度脂肪肝,仅10%病例为中度脂肪肝,而且均与空白组的表现接近。结论:油茶籽油具有辅助降血脂作用以及预防脂肪肝的作用。

关键词: 油茶籽油, 大鼠, 血脂, 脂肪肝

Abstract: Purpose: To evaluate the effects of tea seed oil on reducing blood lipid and preventing fatty liver in rats. Methods: SD rats were fed for 4 days and then randomly assigned into six groups of 10 rats each: high fat control group (A), blank control group (B), high-dose tea seed oil group (C), medium-dose tea seed oil group (D), low-dose tea seed oil group (E) and olive oil control group (F). The daily food intake per kilogram of body weight of group A was 150 g high fat diet + 9.0 g normal saline, of group B 150 g basal diet + 9.0 g normal saline, of group C 150 g high fat diet + 9.0 g tea seed oil, of group D 150 g high fat diet + 3.0 g tea seed oil, of group E 150 g high fat diet + 1.5 g tea seed oil, and of group F 150 g high fat diet + 9.0 g olive oil. High fat models were established by feeding high fat diet. After feeding for 7 consecutive weeks, all rats were killed to determine the levels of serum TG, TC and HDL-C and to observe pathological changes in the liver. Results: Serum TG and TC levels were significantly decreased in tea seed oil-treated rats compared with the high fat control group (P < 0.01), and slighter pathological changes were observed in the liver of tea seed oil-treated rats (P < 0.05). Moreover, the high-dose tea seed oil group and the olive oil control group had similar pathological changes, with 90% normal or light degree fatty liver and 10% middle degree fatty live, which all exhibited manifestations similar to those of the blank control group. Conclusion: Tea seed oil has blood lipid-lowering and fatty liver-preventing effects.

Key words: tea seed oil, rat, blood lipid, fatty liver

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