食品科学 ›› 2011, Vol. 32 ›› Issue (21): 229-232.doi: 10.7506/spkx1002-6630-201121047

• 营养卫生 • 上一篇    下一篇

共轭亚油酸对小鼠的减肥作用

李琪玲,王 武*,章立新   

  1. 合肥工业大学生物与食品工程学院
  • 收稿日期:2018-06-20 修回日期:2018-06-20 出版日期:2011-11-15 发布日期:2011-11-11

Effect of Conjugated Linoleic Acid on Weight Loss of Obesity Mice

LI Qi-ling,WANG Wu*,ZHANG Li-xin   

  1. (School of Biology and Food Technology, Hefei University of Technology, Hefei 230009, China)
  • Received:2018-06-20 Revised:2018-06-20 Online:2011-11-15 Published:2011-11-11

摘要: 建立小鼠营养肥胖模型法,以昆明小鼠为实验动物,建模成功后,连续给予小鼠灌胃共轭亚油酸(CLA)4周,观察CLA对小鼠质量、体脂、血脂、肝脏脂肪酸合成酶(FAS)的影响,并探讨肝脏脂肪酸合成酶与肥胖的相关性。结果表明:CLA各剂量组小鼠Lee’s指数、脂肪系数、血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、肝脏脂肪酸合成酶(FAS)含量与肥胖模型对照组相比均有极显著差异(α=0.01),高密度脂蛋白(HDL-C)高剂量与肥胖模型对照组相比有极显著差异(α=0.01),FAS含量与Lee’s指数、脂肪系数、HDL-C、LDL-C均有一定的相关性,说明CLA具有减肥作用,进一步证实了FAS是导致肥胖的潜在靶点这一观点。

关键词: 共轭亚油酸, 小鼠, 减肥, 脂肪酸合成酶

Abstract: The effect of intragastric administration of conjugated linoleic acid (CLA) for 4 consecutive weeks on body weight, body fats, blood lipids and liver fatty acid synthase in animal models of dietary obesity created using Kunming mice. Meanwhile, the correlation between FAS and obesity was also explored. The results showed that Lee,s index, fat coefficient, serum total cholesterol (TC), serum total triglyceride (TG), serum low density lipoprotein cholesterol (LDL-C) and liver FAS in obese mice administered with CLA at the dosages investigated exhibited a significant difference from those in obese mouse models. Moreover, an obvious correlation between FAS and Lee,s index, fat coefficient or blood lipid was observed. Therefore, CLA has effective weight-lowering effect. Furthermore, the view that FAS is the potential target of obesity is further confirmed.

Key words: conjugated linoleic acid, mouse, weight loss, fatty acid synthase

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