食品科学 ›› 2011, Vol. 32 ›› Issue (21): 301-305.doi: 10.7506/spkx1002-6630-201121061

• 专题论述 • 上一篇    下一篇

3T3-L1前脂肪细胞在功能性成分评价中的应用

蔡教英,刘 姚,王文君*,杨武英   

  1. 江西农业大学 江西省天然产物开发与利用高校重点实验室
  • 出版日期:2011-11-15 发布日期:2011-11-11
  • 基金资助:
    国家自然科学基金面上项目(31160319);江西省科技厅重点项目(2009BGA01900);      江西省自然科学基金项目(2009GZN0014);江西省教育厅科学研究项目(GJJ11403)

Application of 3T3-L1 Preadipocytes in the Evaluation of Functional Components: A Review of the Literature

CAI Jiao-ying,LIU Yao,WANG Wen-jun*,YANG Wu-ying   

  1. (Key Laboratory for Natural Product Utilization and Development of Jiangxi Provincial High School, Jiangxi Agricultural University, Nanchang 330045, China)
  • Online:2011-11-15 Published:2011-11-11

摘要: 脂肪细胞的增殖与分化异常是导致人类肥胖、心血管疾病和Ⅱ型糖尿病等的发生的主要原因,而3T3-L1前脂肪细胞是国际上公认的研究脂肪代谢的细胞模型,因此脂肪细胞的增殖与分化已成为研究的热点。本文主要论述3T3-L1前脂肪细胞的体外培养、增殖与分化及调控及其在功能性成分的评价中的应用,以期为预防和治疗肥胖及糖尿病等并发症提供一定的理论参考。

关键词: 3T3-L1前脂肪细胞, 增殖, 分化, 功能性成分

Abstract: The anomaly of adipocyte proliferation and differentiation plays a key role in the development of obesity, cardiovascular disease and non-insulin-dependent diabetes. 3T3-L1 preadipocyte is a well-accepted model cell for study on adipogenesis. Recently the proliferation and differentiation of adipocytes have become a hot research topic. In this paper, the in vitro culture of 3T3-L1 preadipocyte, mechanisms regulating 3T3-L1 preadipocyte proliferation and differentiation and the application thereof in the evaluation of functional components are reviewed with the purpose to provide some references for the prevention and therapy of obesity and diabetes mellitus.

Key words: 3T3-L1 preadipocytes, proliferation, differentiation, functional components

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