新型苯甲酰吡唑啉酮缩α-丙氨酸席夫碱Ni(II)配合物的合成及抑菌性能研究

doi:10.7506/spkx1002-6630-201123022

食品科学 ›› 2011, Vol. 32 ›› Issue (23): 116-120.doi: 10.7506/spkx1002-6630-201123022

新型苯甲酰吡唑啉酮缩α-丙氨酸席夫碱Ni(II)配合物的合成及抑菌性能研究

刘新文1，张彦翠2，董文魁2，张宗舟1

1.天水师范学院生命科学与化学学院 2.兰州交通大学化工学院

出版日期:2011-12-15 发布日期:2011-12-21
基金资助:
甘肃省新型分子材料设计与功能重点实验项目

Synthesis and Antibacterial Activity of a New Ni (II) Complex of Prazolone and Alpha-Alanine Shiff Base

LIU Xin-wen1，ZHANG Yan-cui2，DONG Wen-kui2，ZHANG Zong-zhou1

(1. College of Life Science and Chemistry, Tianshui Normal University, Tianshui 741001, China； 2. College of Chemical Engineering, Lanzhou Communication University, Lanzhou 730070, China)

Online:2011-12-15 Published:2011-12-21

摘要/Abstract

摘要： 设计并合成4-苯甲酰基吡唑啉酮(PMBP)缩α-丙氨酸席夫碱配体及过渡金属Ni(II)配合物。采用元素分析、红外光谱、差热-热重、紫外光谱法研究其配位结构和理化性质，测定配体及配合物对大肠杆菌、金黄色葡萄球菌的抑菌性能，并选择配合物对昆明种小鼠进行毒理和致畸实验。结果表明：配体以酮式和烯醇式结构共存，配位时以烯醇式发生羟基去质子化结构同金属离子配合；配体及配合物都表现出较好的抑菌能力，但配合物的抑菌性能明显强于配体，且对两种不同菌体存在显著差异；急性毒理、微核和精子畸形实验均为阴性反应，表明目标配合物对小鼠无毒副和致畸作用。因此，配合物作为新型抑菌剂是安全可行的。

关键词: 苯甲酰吡唑啉酮, α-丙氨酸, Ni(Ⅱ)配合物, 抑菌性能, 毒理试验

Abstract: A new ligand containing 1-phenyl-3-methyl-4-benzoyl-5-pyrazolone and α-alanine and its Ni (II) complex was synthesized by refluxing reaction. Their coordination structure and physicochemical properties were characterized using elemental analyzer, IR spectroscopy and UV spectroscopy, their antibacterial activity against Eschetichia coli and Staphylococcus aureus was studied, and their toxicology and teratogenicity of the complex was tested towards KM white mice. The results indicated that the ligand in a keto-form structure could be turned into an enol-form structure after coordination. Both the ligand and its complex had certain antibacterial activity. However, the bacterial activity of the complex was obviously stronger than that of the ligand. Acute toxicity test showed that the complex was non-toxic. Moreover, micronucleus and teratogenicity tests were negative, suggesting that the complex is safe for mammals. Therefore, it is safe and feasible as a new antibacterial agent.

Key words: pyrazolone, alanine, Ni(Ⅱ) complex, antibacterial activity, toxicology test

中图分类号:

TS201.3

刘新文，张彦翠，董文魁，张宗舟. 新型苯甲酰吡唑啉酮缩α-丙氨酸席夫碱Ni(II)配合物的合成及抑菌性能研究[J]. 食品科学, 2011, 32(23): 116-120.

LIUXin-wen，ZHANGYan-cui，DONGWen-kui，ZHANGZong-zhou. Synthesis and Antibacterial Activity of a New Ni (II) Complex of Prazolone and Alpha-Alanine Shiff Base[J]. FOOD SCIENCE, 2011, 32(23): 116-120.

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新型苯甲酰吡唑啉酮缩α-丙氨酸席夫碱Ni(II)配合物的合成及抑菌性能研究

Synthesis and Antibacterial Activity of a New Ni (II) Complex of Prazolone and Alpha-Alanine Shiff Base

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