肠道黏液层降解菌Akkermansia muciniphlia和肠道屏障功能关系研究进展

doi:10.7506/spkx1002-6630-201819045

食品科学 ›› 2018, Vol. 39 ›› Issue (19): 296-302.doi: 10.7506/spkx1002-6630-201819045

肠道黏液层降解菌Akkermansia muciniphlia和肠道屏障功能关系研究进展

高志鹏，吴华，耿欣，宋靖仪，张凯奇，肖俊松*

北京工商大学北京食品营养与人类健康高精尖创新中心，北京市食品添加剂工程技术研究中心，北京市植物资源研究开发重点实验室，北京 100048

出版日期:2018-10-15 发布日期:2018-10-24
基金资助:
北京市自然科学基金项目（7162028）；“十三五”国家重点研发计划重点专项（2016YFD0400801）；北京工商大学两科基金培育项目（LKJJ2016-18）

Recent Advances in the Relationship between Akkermansia muciniphlia and Intestinal Barrier Function

GAO Zhipeng, WU Hua, GENG Xin, SONG Jingyi, ZHANG Kaiqi, XIAO Junsong*

Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Key Laboratory of Plant Resource Research and Development, Beijing Technology and Business University, Beijing 100048, China

Online:2018-10-15 Published:2018-10-24

摘要/Abstract

摘要： 肠道屏障功能异常与肥胖等一系列慢性代谢性疾病相关。Akkermansia muciniphlia是一种肠道黏液层降解菌，与肠道屏障功能关系密切，其丰度在部分代谢性疾病临床病例和动物模型中变化显著，提示该菌可能参与代谢，但具体作用机制有待明确和归纳。本文从A. muciniphlia与肠道黏液层、代谢疾病以及肠道免疫关系这3 个角度，综述了近年来相关研究进展，试图探讨该菌对肠道屏障功能的影响和作用机制，为通过饮食预防慢性代谢疾病提供新的思路。

关键词: Akkermansia muciniphlia, 肠道屏障功能, 慢性代谢疾病, 丰度

Abstract: Intestinal barrier dysfunction is associated with some chronic metabolic diseases, such as obesity and diabetes. Akkermansia muciniphlia, a mucin-degrading bacterium that resides in the mucus layer, is closely related to intestinal barrier function. Significant changes in the abundance of this bacterium in clinical cases and some animal models of metabolic diseases suggest its possible involvement in the progression of metabolic diseases. However, the exact mechanism of action remains to be clarified. This article reviews recent advances in the relationship of A. muciniphlia with the intestinal mucus layer, metabolic diseases and intestinal immunity, and also attempts to elucidate the influence and mechanism of action of this bacterium on intestinal barrier function. It is hoped that this review will provide new insights into dietary prevention of chronic metabolic diseases.

Key words: Akkermansia muciniphlia, intestinal barrier function, chronic metabolic diseases, abundance

中图分类号:

TS201.3

高志鹏，吴华，耿欣，宋靖仪，张凯奇，肖俊松. 肠道黏液层降解菌Akkermansia muciniphlia和肠道屏障功能关系研究进展[J]. 食品科学, 2018, 39(19): 296-302.

GAO Zhipeng, WU Hua, GENG Xin, SONG Jingyi, ZHANG Kaiqi, XIAO Junsong. Recent Advances in the Relationship between Akkermansia muciniphlia and Intestinal Barrier Function[J]. FOOD SCIENCE, 2018, 39(19): 296-302.

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肠道黏液层降解菌Akkermansia muciniphlia和肠道屏障功能关系研究进展

Recent Advances in the Relationship between Akkermansia muciniphlia and Intestinal Barrier Function

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