食品科学 ›› 2019, Vol. 40 ›› Issue (3): 173-177.doi: 10.7506/spkx1002-6630-20171030-359

• 营养卫生 • 上一篇    下一篇

中国野生蓝莓对非酒精性脂肪肝的保肝效果

丁欢欢1,景志行2,许剑锋1,*,刘海泉2,赵?勇2,3   

  1. (1.上海海洋大学食品学院,上海 201306;2.上海水产品加工及贮藏工程技术研究中心,上海 201306;3.农业部水产品贮藏保鲜质量安全风险评估实验室(上海),上海 201306)
  • 出版日期:2019-02-15 发布日期:2019-03-05
  • 基金资助:
    上海市教育委员会科研创新计划项目(2017-01-07-00-10-E00056)

Hepatoprotective Effect of Wild Blueberry Grown in China on Non-alcoholic Fatty Liver Disease

DING Huanhuan1, JING Zhixing2, XU Jianfeng1,*, LIU Haiquan2, ZHAO Yong2,3   

  1. (1. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China; 2. Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China; 3. Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai 201306, China)
  • Online:2019-02-15 Published:2019-03-05

摘要: 目的:研究中国野生蓝莓对非酒精性脂肪肝的保肝效果。方法:经灌胃给予高脂诱导肥胖小鼠低(10?g/(kg·d))、中(20?g/(kg·d))、高(40?g/(kg·d))剂量蓝莓匀浆和低(0.006?g/(kg·d))、中(0.012?g/(kg·d))、高(0.024?g/(kg·d))剂量野生蓝莓总花青素6?周后,分别测定小鼠血清天冬氨酸氨基转移酶(aspartate amino transferase,AST)、丙氨酸氨基转移酶(alanine amino transferase,ALT)活力,总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)浓度,肝组织匀浆液的总抗氧化能力(total antioxidant capacity,T-AOC)和谷胱甘肽(glutathione,GSH)、丙二醛(malondialdehyde,MDA)含量。结果:与脂肪肝模型组小鼠相比,中国野生蓝莓匀浆中剂量组和总花青素中、高剂量组可以有效降低非酒精性脂肪肝小鼠血清AST、ALT的活力(P<0.05);蓝莓匀浆中、高剂量组能有效调节LDL-C浓度(P<0.05);蓝莓匀浆和花青素各剂量组均能显著降低TC、TG浓度(P<0.05);蓝莓匀浆中、高剂量组和花青素中、高剂量组能明显增加小鼠肝组织的T-AOC和GSH含量,降低MDA含量(P<0.05)。结论:中国野生蓝莓总花青素对非酒精性脂肪肝有良好的保肝效果。

关键词: 中国野生蓝莓, 花青素, 非酒精性脂肪肝, 保肝作用

Abstract: Objective: To investigate the hepatoprotective effect of wild blueberry grown in China on non-alcoholic fatty liver disease. Methods: High-fat diet-induced obese mice were administrated with low, medium and high-dose blueberry homogenate (10, 20 and 40 g/(kg·d)) or blueberry anthocyanins (0.006, 0.012 and 0.024 g/(kg·d)) by gavage for 6 weeks. Then the activities of aspartate amino transferase (AST) and alanine amino transferase (ALT), and the contents of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) in the sera of the mice as well as total antioxidant capacity (T-AOC) and the contents of glutathione (GSH) and malondialdehyde (MDA) in liver homogenates were determined. Results: Compared with the fatty liver model group, low-dose blueberry homogenate and medium- and high-dose blueberry anthocyanins significantly reduced the activities of AST and the ALT in mice (P < 0.05). Medium- and high-dose blueberry homogenate improved LDL-C content. Both the homogenate and anthocyanins at all doses significantly decreased TC and TG contents (P < 0.05) and at the medium and high doses could significantly increase T-AOC and GSH content and reduce MDA content in the liver of mice (P < 0.05). Conclusion: Anthocyanins from wild blueberry grown in China have good protective effects on non-alcoholic fatty liver disease.

Key words: wild blueberry grown in China, anthocyanin, non-alcoholic fatty liver, hepatoprotective effect

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