大蒜油和洋葱油对四氧嘧啶致糖尿病小鼠降血糖作用

doi:10.7506/spkx1002-6630-201023076

食品科学 ›› 2010, Vol. 31 ›› Issue (23): 344-348.doi: 10.7506/spkx1002-6630-201023076

大蒜油和洋葱油对四氧嘧啶致糖尿病小鼠降血糖作用

李莉华，吕慧，杨立刚，王少康，孙桂菊* ，苗苗，左平国，贾根梅，宋志秀，张朋，沈洁

东南大学公共卫生学院营养与食品卫生系

收稿日期:2010-06-10 出版日期:2010-12-15 发布日期:2010-12-29
通讯作者: 孙桂菊 E-mail:gjsun@seu.edu.cn
基金资助:
江苏省科技攻关项目 (BE2007407)

Hypoglycemic Effects of Garlic oil and Onion oil on Alloxan Diabetic Mice

LI Li-hua，LU Hui，YANG Li-gang，WANG Shao-kang，SUN Gui-ju*，MIAO Miao，ZUO Ping-guo，
JIA Gen-mei，SONG Zhi-xiu，ZHANG Peng，SHEN Jie

Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China

Received:2010-06-10 Online:2010-12-15 Published:2010-12-29
Contact: SUN Gui-ju E-mail:gjsun@seu.edu.cn

摘要/Abstract

摘要：

目的：研究大蒜油和洋葱油对糖尿病小鼠的降血糖作用。方法：小鼠腹腔注射四氧嘧啶建立糖尿病动物模型，以不同剂量的大蒜油和洋葱油分别灌胃给予糖尿病小鼠30d，测定0、30d 时空腹血糖值和30d 时糖耐量。动物处死后，取血液测定小鼠糖化血清蛋白、尿素氮含量及血脂水平。结果：以92.6mg/(kg bw·d)灌胃给予模型小鼠大蒜油或洋葱油30d，其空腹血糖值、血糖曲线下面积、尿素氮、糖化血清蛋白水平均低于模型对照组小鼠，且有显著性差异(P ＜ 0.05)，对糖尿病小鼠肝肾及胰岛损伤亦有不同程度的保护作用。结论：大蒜油和洋葱油对糖尿病小鼠具有降血糖作用，并对糖尿病引起的肝肾及胰岛损伤有保护作用。

关键词: 四氧嘧啶, 糖尿病小鼠, 大蒜油, 洋葱油, 降血糖

Abstract:

Objective:To study the hypoglycemic effects of garlic oil and onion oil on diabetic mice. Methods: The diabetic mice induced by alloxan in different groups were fed with different dose of garlic oil or onion oil for 30-day continuously. Fasting blood glucose was determined on day 0 and 30, while glucose tolerance level was determined on day 30. The blood samples of mice were collected for the analysis of glycosylated serum protein and blood urea nitrogen as well as lipid levels. Results: There were significant differences between the diabetic mice given garlic oil or onion oil at the dose of 92.6 mg/(kg bw·d) and model group mice on the levels of fasting blood glucose, glucose area under curve, the levels of blood urea nitrogen, glycosylated serum protein (P＜0.05). Further more, garlic oil and onion oil at the dose of 92.6 mg/(kg bw·d) had protection on liver, kidney and pancreatic damage in diabetic mice. Conclusion: The garlic oil and onion oil had the hypoglycemic effects on diabetic mice, and they also had protective effects on liver and kidney as well as pancreatic injury caused by diabetes mellitus.

Key words: Alloxan, diabetic mice, garlic oil, onion oil, hypoglycemic effects

中图分类号:

TS255.1

李莉华，吕慧，杨立刚，王少康，孙桂菊*,苗苗，左平国，贾根梅，宋志秀，张朋，沈洁. 大蒜油和洋葱油对四氧嘧啶致糖尿病小鼠降血糖作用[J]. 食品科学, 2010, 31(23): 344-348.

LI Li-hua，LU Hui，YANG Li-gang，WANG Shao-kang，SUN Gui-ju*，MIAO Miao，ZUO Ping-guo，. Hypoglycemic Effects of Garlic oil and Onion oil on Alloxan Diabetic Mice[J]. FOOD SCIENCE, 2010, 31(23): 344-348.

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大蒜油和洋葱油对四氧嘧啶致糖尿病小鼠降血糖作用

Hypoglycemic Effects of Garlic oil and Onion oil on Alloxan Diabetic Mice

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