甘草苷抗脑缺血再灌注炎性损伤研究

doi:10.7506/spkx1002-6630-201023078

食品科学 ›› 2010, Vol. 31 ›› Issue (23): 353-355.doi: 10.7506/spkx1002-6630-201023078

甘草苷抗脑缺血再灌注炎性损伤研究

孙雅煊^{1 , 2}，刘婷³，戴雪伶¹，高兆兰¹，魏荣¹，郑秋生³

1.北京联合大学应用文理学院
2. 中国科学院寒区旱区环境与工程研究所
3. 石河子大学药学院

收稿日期:2010-03-23 出版日期:2010-12-15 发布日期:2010-12-29
通讯作者: 孙雅煊 E-mail:sunxx@ygi.edu.cn
基金资助:
北京联合大学校级课题资助项目(zk200905x)

Protective Effect of Liquiritin against Cerebral Ischemia/Reperfusion Inflammatory Injury in Mice

SUN Ya-xuan1,2，LIU Ting3，DAI Xue-ling1，GAO Zhao-lan1，WEI Rong1，ZHENG Qiu-sheng3

1. College of Appllied Sciences and Humanities, Beijing Union University, Beijing 100191, China；
2. Cold and Arid Regions Environmental and Engineering Research Institute, Chinese Academy of Sciences, Lanzhou 730000, China；
3. Department of Pharmacy, Shihezi University, Shihezi 832003, China

Received:2010-03-23 Online:2010-12-15 Published:2010-12-29
Contact: SUN Ya-xuan E-mail:sunxx@ygi.edu.cn

摘要/Abstract

摘要：

目的：探讨甘草苷抗小鼠脑缺血再灌注炎性损伤作用及机制。方法：将ICR 小鼠随机分为假手术组、模型组、阳性对照组(依达拉奉3mg/(kg bw·d)和甘草苷高、中、低剂量(40、20、10mg/(kg bw·d))组。采用线栓法建立局灶性脑缺血再灌注损伤模型，缺血2h 再灌注22h 后，观察脑组织病理学变化、测定髓过氧化物酶(MPO)活性，检测细胞间黏附因子-1(ICAM-1)表达。结果：与模型组相比，甘草苷可明显减轻脑组织病理学改变，降低MPO 活性及ICAM-1 表达。结论：甘草苷具有抗脑缺血再灌注炎性损伤活性。

关键词: 甘草苷, 脑缺血再灌注, 炎性损伤, 髓过氧化物酶, 细胞间黏附因子-1

Abstract:

Objective: To investigate the protective effect and mechanism of liquiritin against cerebral ischemia/reperfusion inflammatory injury in mice. Methods: ICR mice were randomly divided into sham group, model group, positive control group (intraperitoneally administered edaravone, 3 mg/(kg bw·d)), and liquiritin groups (intragastrically administered, 40, 20 mg/(kg bw·d) and 10 mg/(kg bw·d)). Focal cerebral ischemia/reperfusion models were set up by using intraluminal filament method. After cerebral ischemia for 2 h and subsequent reperfusion for 22 h, histopathology changes were monitored, and the activity of MPO and the expression of intercellular adhesion molecule-1(ICAM-1) in brain tissue were measured. Results: Compared with the model group, liquiritin noticeably decreased the activity of MPO and the expression of ICAM-1. Conclusion: Liquiritin has protective effects against cerebral ischemic/reperfusion inflammatory injury.

Key words: liquiritin, cerebral ischemia/reperfusion, inflammatory injury, MPO, intercellular adhesion molecule-1

中图分类号:

R931.71

孙雅煊1,2，刘婷3，戴雪伶1，高兆兰1，魏荣1，郑秋生3. 甘草苷抗脑缺血再灌注炎性损伤研究[J]. 食品科学, 2010, 31(23): 353-355.

SUN Ya-xuan1,2，LIU Ting3，DAI Xue-ling1，GAO Zhao-lan1，WEI Rong1，ZHENG Qiu-sheng3. Protective Effect of Liquiritin against Cerebral Ischemia/Reperfusion Inflammatory Injury in Mice[J]. FOOD SCIENCE, 2010, 31(23): 353-355.

甘草苷抗脑缺血再灌注炎性损伤研究

Protective Effect of Liquiritin against Cerebral Ischemia/Reperfusion Inflammatory Injury in Mice

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

编辑推荐

Metrics

本文评价