食品科学 ›› 2010, Vol. 31 ›› Issue (23): 360-365.doi: 10.7506/spkx1002-6630-201023080

• 营养卫生 • 上一篇    下一篇

添加乳蛋白水解物的配方奶粉的免疫功能评价

孟维彬1,胡志和1 ,* ,王丽娟1,冯永强2,朱利民2   

  1. 1.天津市食品生物技术重点实验室,天津商业大学生物技术与食品科学学院 2.天津海河乳业有限公司
  • 收稿日期:2010-06-27 修回日期:2010-11-10 出版日期:2010-12-15 发布日期:2010-12-29
  • 通讯作者: 胡志和 E-mail:hzhihe@tjcu.edu.cn
  • 基金资助:

    天津市科技支撑计划重点项目(07ZCKFNC00200)

Evaluation of Immunoregulatory Function of Formula Milk Powder Added with Lactoprotein Hydrolysates

MENG Wei-bin1, HU Zhi-he1,*, WANG Li-juan1, FENG Yong-qiang2, ZHU Li-min2   

  1. 1.Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of
    Commerce, Tianjin 300134, China;2. Tianjin Haihe Dairy Co. Ltd., Tianjin 300402, China
  • Received:2010-06-27 Revised:2010-11-10 Online:2010-12-15 Published:2010-12-29
  • Contact: HU Zhi-he E-mail:hzhihe@tjcu.edu.cn

摘要:

根据我国免疫调节功能食品的评价方法,对添加乳蛋白水解物的免疫增强乳制品的免疫调节作用进行评价。在实验中,采用Balb/c 小鼠建立免疫低下模型,以不同剂量的配方奶粉对小鼠进行灌胃实验,分别进行免疫脏器质量、细胞免疫功能、体液免疫功能、单核- 巨嗜细胞功能等指标检测。结果表明:在所选定的剂量范围内,添加乳源蛋白水解物的老年奶粉和婴幼儿(三段)奶粉结果均为阳性,因此可判定配方奶粉具有免疫增强作用。

关键词: 乳蛋白水解物, 配方奶粉, 免疫调节功能

Abstract:

To understand the immunoregulatory function of formula milk powder added with lactoprotein hydrolysates, different doses of infant formula milk powder and middle-aged and senior formula milk powder with and without the additions of casein and milk whey protein hydrolysates were orally administered to the Balb/c mouse model with immunosuppression induced by intraperitoneal injection of cyclophosphate (Cy) for 15 successive days, respectively. Spleen index, thymus index, cellular immune response, humoral immune function and phagocytic function of mononuclear macrophage were determined on the second day after the last administration. It was found that the evaluation results of infant formula milk powder and middleaged and senior formula milk powder added with lactoprotein hydrolysates were both positive, thus proving that adding lactoprotein hydrolysates enhances the immunoregulatory function of formula milk powder.

Key words: lactoprotein hydrolysates, formula milk powder, immunoregulatory function

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