食品科学 ›› 2010, Vol. 31 ›› Issue (19): 339-341.doi: 10.7506/spkx1002-6630-201019074

• 营养卫生 • 上一篇    下一篇

蛹虫草对衰老小鼠脑、肝组织氧化酶的影响

杨占军,张 健,汤 阳,温 鲁   

  1. 淮阴师范学院生命科学院
  • 收稿日期:2009-12-16 出版日期:2010-10-15 发布日期:2010-12-29
  • 通讯作者: 杨占军 E-mail:yzj5678@163.com
  • 基金资助:

    江苏省高校自然科学基金项目(05KJB180010);淮阴师范学院教授基金项目(06HSJS027)

Effect of Cordyceps militaris on Oxidases in Brain and Liver Tissues of D-Galactose-induced Senile Mice

YANG Zhan-jun,ZHANG Jian,TANG Yang,WEN Lu   

  1. School of Life Science, Huaiyin Normal University, Huai’an 223300, China
  • Received:2009-12-16 Online:2010-10-15 Published:2010-12-29
  • Contact: YANG Zhan-jun E-mail:yzj5678@163.com

摘要:

目的:以衰老相关酶为指标,探讨蛹虫草对D- 半乳糖致衰老小鼠的影响。方法:使用D- 半乳糖建立小鼠衰老模型,用蛹虫草灌胃进行实验性治疗。持续6 周后,测定脑和肝组织的总抗氧化能力(T-AOC)、谷胱甘肽过氧化物酶(GSH-Px)、单胺氧化酶(MAO)活性和丙二醛(MDA)含量。结果:与对照组相比,模型组小鼠的T-AOC、GSH-Px 活性降低,MAO 活性和MDA 含量升高(P < 0.05 或 P < 0.01),说明造模成功;与模型组相比,蛹虫草组的T-AOC、GSH-Px 活性有不同程度地恢复,MAO 活性和MDA 含量降低(P < 0.05)。结论:蛹虫草可提高小鼠脑、肝组织的抗氧化能力。

关键词: 蛹虫草, D-半乳糖, 衰老, 氧化酶

Abstract:

Objective: The enzymes related to aging were used as the indexes to explore the effect of Cordyceps militaris on Dgalactose-induced senile mice. Methods: A mouse model with senile disturbance of brain tissue was established by D-galactose induction and the experimental mice were treated with Cordyceps militaris by gavage. After the administration of Cordyceps militaris for six weeks, the activities of T-AOC, GSH-Px, MAO and the content of MDA in brain and liver tissues were analyzed. Results: Compared with the control group, the activities of T-AOC and GSH-Px of the model group exhibited an obvious decrease, and the activity of MAO and the content of MDA exhibited a significant increase (P < 0.05 or P < 0.01). Compared with the model group, the activities of T-AOC and GSH-Px in mice administered with Cordyceps militaris was ameliorated, and the activity of MAO and the content of MDA exhibited an obvious decrease (P < 0.05). Conclusion: Cordyceps militaris can improve the antioxidant capability of brain and liver tissues.

Key words: Cordyceps militaris, D-galactose, senile, oxidase

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