食品科学 ›› 2010, Vol. 31 ›› Issue (13): 273-275.doi: 10.7506/spkx1002-6630-201013062

• 营养卫生 • 上一篇    下一篇

芦笋总皂苷抗肿瘤作用研究

宋 擎1, 柴秋彦2,张立伟1,*   

  1. 1. 山西大学分子科学研究所
    2. 山西省医药与生命科学研究院
  • 收稿日期:2009-11-24 修回日期:2010-03-31 出版日期:2010-07-01 发布日期:2010-12-29
  • 通讯作者: 张立伟 E-mail:lwzhang@sxu.edu.cn
  • 基金资助:

    山西省科技攻关项目(2006031078);太原市科技局大学生创新项目(07010789)

in vivo Anti-tumor Activity of Total Saponins from Asparagus officinalis

SONG Qing1,CHAI Qiu-yan2,ZHANG Li-wei1,*   

  1. 1. Institute of Molecular Science, Shanxi University, Taiyuan 030006, China ;
    2. Shanxi Academy of Medicine and Life Science, Taiyuan 030006, China
  • Received:2009-11-24 Revised:2010-03-31 Online:2010-07-01 Published:2010-12-29
  • Contact: ZHANG Li-wei1,* E-mail:lwzhang@sxu.edu.cn

摘要:

利用荷瘤小鼠观察研究芦笋总皂苷对移植性肿瘤S180、H22 的体内抗肿瘤活性和对免疫器官质量的影响。结果表明:芦笋总皂苷对S180 和H22 荷瘤小鼠的肿瘤生长有明显抑制作用,高剂量组对S180 和H22 抑瘤率分别达到39.53%(P < 0.05)和34.81%(P < 0.01),并呈现良好的量效关系。

关键词: 芦笋, 总皂苷, 抗肿瘤

Abstract:

The anti-tumor activity and immune regulation activity of total saponins from Asparagus officinalis were investigated by determining tumor weight and immune organ weight. The results indicated that total saponins from Asparagus officinalis had significant dose-dependent inhibitory effects on the growth of sarcoma S180 (S180) and hepatoma H22 (H22) cells implanted into healthy mice. The inhibition rate in high-dose group was 39.53% (P < 0.05) on S180 and 34.81% (P < 0.01) on H22 cells.

Key words: Asparagus officinalis, total saponins, anti-tumor activity

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