食品科学 ›› 2010, Vol. 31 ›› Issue (11): 234-237.doi: 10.7506/spkx1002-6630-201011050

• 营养卫生 • 上一篇    下一篇

植物雌激素对老年性大鼠股骨生物力学特性的影响

赵丽英1,张二芹1,刘 声2,杜瑞卿1 ,* ,高允海3,黄 豪4   

  1. 1.南阳师范学院生命科学与技术学院 2.北京中医药大学基础医学院 3.辽宁中医药大学第一附属医院普外科 4.南阳师范学院体育学院
  • 收稿日期:2009-09-23 出版日期:2010-06-01 发布日期:2010-12-29
  • 通讯作者: 杜瑞卿 E-mail:duruiqing8@163.com
  • 基金资助:

    河南省教育厅基础研究资助项目(2007890009);南阳师范学院生物化学与分子生物学重点学科资助项目

Effect of Soybean Meal Derived Phytoestrogen on Biomechanical Characteristics of Femur in Senile Rats

ZHAO Li-ying1,ZHANG Er-qin1,LIU Sheng2,DU Rui-qing1,*,GAO Yun-hai3,HUANG Hao4   

  1. 1. School of Life Science and Technology, Nanyang Normal University, Nanyang 473061, China;
    2. School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, China;
    3. Department of General Surgery, First Hospital of Liaoning Traditional Medicine University, Shenyang 110032, China;
    4. College of Physical Education, Nanyang Normal University, Nanyang 473061, China
  • Received:2009-09-23 Online:2010-06-01 Published:2010-12-29
  • Contact: DU Rui-qing E-mail:duruiqing8@163.com

摘要:

目的:揭示植物雌激素对老年性骨生物力学的影响程度。方法:选取120 只老龄性SD 清洁级大鼠,分成4 组,每组分别喂养3 个月、6 个月和10 个月的不同批次处死,取股骨测量6 项生物力学指标,并进行统计分析。结果:植物雌激素在10 个月、6 个月和3 个月不同时期都表现出能增强骨生物力学特性的作用,能改善骨质量;而单纯依靠增加钙剂量在6 个月和3 个月内作用却不明显,10 个月内可以改善骨生物力学的特性,但不全面;在使用植物雌激素的同时,增加钙含量,对改善骨生物力学的特性更好。结论:单纯食钙对预防骨质疏松症和改善骨质量的作用有限,经常适量食用含植物雌激素丰富的大豆或大豆制品对预防骨质疏松症和较全面改善骨质量有积极意义。

关键词: 植物雌激素, 骨生物力学特性, 实验研究

Abstract:

Objective: To evaluate the effect of phytoestrogen contained in soybean meal on biomechanical characteristics of bone in senile rats. Methods: Totally 120 senile male SD rats were randomly divided into 4 groups, which were fed common diet (as the control), common diet plus calcium, common diet plus phytoestrogens, and common diet plus calcium and phytoestrogen, respectively. The rats in every group were partially sacrificed after 3, 6 or 10 months of feeding. The biomechanical characteristics of the femur in senile rats were analyzed. Results: The administration of phtoestrogen, could enhance biomechanical characteristics and improve bone quality in rats regardless of length of administration time (3, 6 or10 months), which was superior to the administration of calcium alone. The administration of calcium alone for 3 or even 6 months had no obvious beneficial effects on biomechanical characteristics and bone quality in rats; an improvement in some but not all of biomechanical characteristics in rats, howevers observed when the length of administration time was prolonged to 10 months. In the presence of phytoestrogen, increasing calcium amount resulted in a better improvement in biomechanical characteristics. Conclusion: The intake of calcium alone has a limited effect in preventing osteoporosis and in improving bone quality. Comparatively, the frequent consumption of soybean or soybean products has positive significance for preventing osteoporosis and improve bone quality.

Key words: phytoestrogen, biomechanical characteristics, experimental investigation

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