食品科学 ›› 2010, Vol. 31 ›› Issue (11): 255-257.doi: 10.7506/spkx1002-6630-201011056

• 营养卫生 • 上一篇    下一篇

沙枣多糖抗疲劳作用及其机制的研究

丁玉松1,王 忠2,马儒林1,冯刚玲1,徐上知1,吕凤莲1,唐美娥1,郑荣华1   

  1. 1.新疆石河子大学医学院预防医学系 2.新疆医科大学医学实验动物中心
  • 收稿日期:2009-11-09 出版日期:2010-06-01 发布日期:2010-12-29
  • 通讯作者: 丁玉松 E-mail:51603030@qq.com
  • 基金资助:

    石河子大学高层次人才科研启动资金专项项目(RCZX200790)

Anti-fatigue Effect and Mechanism of Polysaccharides from Eleagnus angustifolius L.

DING Yu-song1,WANG Zhong2,MA Ru-lin1,FENG Gang-ling1,XU Shang-zhi1,LU Feng-lian1,TANG Mei-e1,ZHENG Rong-hua1   

  1. 1. Department of Public Health, College of Medicine, Shihezi University, Shihezi 832003, China;
    2. Medical Laboratory Animal Center, Xinjiang Medical University, Urumqi 830054, China
  • Received:2009-11-09 Online:2010-06-01 Published:2010-12-29
  • Contact: DING Yu-song E-mail:51603030@qq.com

摘要:

目的:探讨沙枣多糖(EAP)的抗疲劳生物功效及其机制。方法:取健康雄性清洁级ICR 小鼠192 只,随机分为4 批,每批48 只,分别进行负重游泳、肝糖原测定、血清尿素氮和血乳酸测定实验。每批动物再随机分为4 组,即正常对照组、EAP 低剂量组(100mg/(kg bw·d))、EAP 中剂量组(500mg/(kg bw·d))、EAP 高剂量组(1000mg/(kg bw·d)),连续灌胃30d 后分别测定负重游泳时间、肝糖原含量、血清尿素氮和血乳酸含量。结果:EAP 中、高剂量组能延长小鼠负重游泳时间;EAP 各剂量组均能增加肝糖原含量;EAP 低、高剂量组能够减少血清尿素氮含量;EAP 中、高剂量组能降低血乳酸含量。结论:EAP 具有明显的抗疲劳作用。

关键词: 沙枣多糖, 抗疲劳, 机制, 保健食品

Abstract:

Objective: To explore the anti-fatigue effect and mechanism of polysaccharides from Eleagnus angustifolius L. Methods: A total of 192 Kunming mice were randomly divided into 4 batches, each of which consisted of 4 groups: EAP groups at the dosages of low (100 mg/(kg bw·d)), middle (500 mg/(kg bw·d)) and high (1000 mg/(kg bw·d)) levels, and the control group. Each mouse was administered once a day for 30 days. After the end of the administration, all the mice were evaluated for their weight-loaded swimming duration and the contents of hepatic glycogen, blood urea nitrogen and blood lactic acid. Results: EAP at the high and middle dosages could prolong weight-loaded swimming duration, and decrease blood lactic acid level of mice. Hepatic glycogen content exhibited an increase in all groups administered EAP. In addition, a decline of blood urea nitrogen was observed in mice administered EAP at the high and low dosages. Conclusion: EAP could alleviate physical fatigue of mice.

Key words: polysaccharides from Eleagnus angustifolius L., anti-fatigue effect, mechanism, health-care food

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