食品科学 ›› 2010, Vol. 31 ›› Issue (11): 298-302.doi: 10.7506/spkx1002-6630-201011065

• 专题论述 • 上一篇    下一篇

河豚毒素及其发酵生产的研究进展

谷江稳1,徐善良2,颜付云1,陈宣雄1   

  1. 1. 宁波大学 海洋生物工程浙江省重点实验室 2.宁波大学 应用海洋生物技术教育部重点实验室
  • 收稿日期:2009-10-19 出版日期:2010-06-01 发布日期:2010-12-29
  • 通讯作者: 徐善良 E-mail:xushanliang@nbu.edu.cn

Research Advances in Tetrodotoxin and Its Fermentation

GU Jiang-wen1,XU Shan-liang2,*,YAN Fu-yun1,CHEN Xuan-xiong1   

  1. 1.Key Laboratory of Marine Biotechnology of Zhejiang, Ningbo University, Ningbo 315211, China ;
    2. Key Laboratory of Applied Marine Biotechnology, Ministry of Education, Ningbo University, Ningbo 315211, China
  • Received:2009-10-19 Online:2010-06-01 Published:2010-12-29
  • Contact: XU Shan-liang2 E-mail:xushanliang@nbu.edu.cn

摘要:

河豚毒素(tetrodotoxin,TTX) 常见于河豚体内,是一种毒性很强的氨基全氢化喹唑啉化合物。它是世界上最致命的生物毒素之一,同时也是对神经有选择性作用的强效麻醉药和戒毒良药。因此,科研人员在弄清TTX的产生途径及产生菌后,正在竭力研究其生产工艺及高产方式,以使其显著的医药学价值为人类所用。本文综述TTX 的起源、理化性质及其生物活性等基本特性,并重点介绍近年的研究方向和热点问题,即TTX 的产生菌和发酵生产等方面的研究。

关键词: 河豚, 河豚毒素, T TX, 产生菌, 发酵

Abstract:

Tetrodotoxin (TTX) is a highly toxic amino hydrogenated quinazoline compound in puffer fish. TTX is one of the most lethal biological toxins. It is also a powerful anesthetic and detoxification agent. Therefore, further studies on preparation technology and high-yield strategies of TTX for extending its medicinal values are being conducted according to the understanding of its generation pathways and TTX-producing strains. In this paper, basic characteristics of TTX including the origin, physical and chemical properties, biological activity are reviewed. In addition, current hot research direction and corresponding issues such as TTX-producing strain and its fermentation are also comprehensively analyzed.

Key words: puffer fish, tetrodotoxin, TTX-producing strain, fermentation

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