食品科学 ›› 2010, Vol. 31 ›› Issue (7): 280-283.doi: 10.7506/spkx1002-6300-201007062

• 营养卫生 • 上一篇    下一篇

水芹正丁醇提取物抗凝血和抗血栓形成作用的研究

朴日龙,张红英*   

  1. 延边大学基础医学院机能学实验中心
  • 收稿日期:2009-06-30 出版日期:2010-04-01 发布日期:2010-12-29
  • 通讯作者: 张红英 E-mail:zhanghongying52@163.com

Anti-coagulation and Anti-thrombosis Effects of n-Butanol Extract from Oenanthe aquatic

PIAO Ri-long,ZHANG Hong-ying*   

  1. Function Test Centre, College of Based Medicine, Yanbian University, Yanji 133000, China
  • Received:2009-06-30 Online:2010-04-01 Published:2010-12-29
  • Contact: ZHANG Hong-ying E-mail:zhanghongying52@163.com

摘要:

目的:研究水芹正丁醇提取物的抗凝血和抗血栓作用。方法:分别通过玻片、毛细管、剪尾法研究水芹正丁醇提取物对小鼠凝血时间、尾出血时间的影响;用Chandler 法及动- 静脉旁路法研究水芹正丁醇提取物对家兔体外血栓和动-静脉旁路血栓形成的影响;同时用Wright 法研究水芹正丁醇提取物对家兔血小板黏附功能的影响。结果:水芹正丁醇提取物(500、250mg/(kg bw·d))能明显延长小鼠凝血时间和出血时间;水芹正丁醇提取物(280、140mg/(kg bw·d))能明显抑制家兔体外血栓和动- 静脉旁路血栓的形成,在同样剂量下,能明显抑制家兔的血小板黏附功能。结论:水芹正丁醇提取物具有抗凝血和抗血栓形成作用。

关键词: 水芹正丁醇提取物, 凝血时间, 出血时间, 血栓形成, 血小板黏附

Abstract:

Objectives: To investigate anti-coagulation and anti-thrombosis effects of n-butanol extract from Oenanthe aquatic. Methods: The effect of n-butanol extract from Oenanthe aquatic on coagulation time and bleeding time of mouse tails was investigated using glass coverslip, capillary and cutting tail methods. Meanwhile, the effect of n-butanol extract from Oenanthe aquatic on thrombosis and thrombosis of arterio-venous bypass in rabbits was studied using Chandle and arterio-venous bypass methods. In addition, the effect of n-butanol extract from Oenanthe aquatic on platelet adhesion function in rabbits was also studied using Wright method. Results: n-butanol extract from Oenanthe aquatic at the doses of 500 mg/(kg bw·d)and 250 mg/(kg bw·d) significantly prolonged coagulation time and bleeding time in mice. When the dose was 280 or 140 mg/(kg bw·d), thrombosis and thrombosis of arterio-venous bypass in rabbits were significantly inhibited and a significant inhibitory effect on platelet adhesion function in rabbits was observed. Conclusion: n-butanol extract from Oenanthe aquatic has anti-coagulation and antithrombosis effects.

Key words: n-butanol extract from Oenanthe aquatic, coagulation time, bleeding time, thrombosis, platelet adhesion

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