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Food Safety and Toxicological Assessment of Eleutheroside

YANG Ping,LI Run-guo,MENG Xian-jun   

  1. 1. College of Grain, Shenyang Normal University, Shenyang 110034, China;
    2. College of Food Science, Shenyang Agricultural University, Shenyang 110161, China
  • Online:2013-06-15 Published:2013-06-03

Abstract:

Objective: To evaluate the safety of eleutheroside, and to provide scientific support for the reasonable utilization
and development of eleutheroside. Methods: According to the national standard procedures and methods in food safety and
toxicological evaluation, a series of toxicological studies on the ingestion of eleutheroside were conducted, which included
acute toxicity, genetic toxicity and subacute toxicity tests. Results: For acute toxicity, the maximum tolerated dose (MTD)
was higher than 20 g/kg. The results of Ames test, mouse bone marrow micronucleus test and mouse sperm abnormality
test were negative. After 30 d of feeding, rats showed no significant difference in body growth, organ development or
histological observation. Conclusion: Eleutheroside is actually non-toxic with no genetic toxicity. No adverse effect of
eleutheroside at 20 g/kg has been observed during trails for 30 d.

Key words: eleutheroside, acute toxicity, genetic toxicity, subacute toxicity, food safety