FOOD SCIENCE ›› 2020, Vol. 41 ›› Issue (4): 262-267.doi: 10.7506/spkx1002-6630-20190326-335

• Safety Detection • Previous Articles     Next Articles

Simultaneous Determination of 3-Monochloropropane-1,2-Diol Esters and Glycidyl Esters in Infant Formula Powder by Isotope Internal Standard-Gas Chromatography-Mass Spectrometry

WANG Ya, GAO Hongbo, SUI Haixia, QIU Kai, ZHONG Qiding, Lü Xiaoling   

  1. (1. College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China;2. China National Research Institute of Food & Fermentation Industries, Beijing 100015, China;3. China National Standardization Center of Food & Fermentation, Beijing 100015, China;4. China National Center for Safety Risk Assessment, Beijing 100022, China)
  • Online:2020-02-25 Published:2020-03-02

Abstract: The aim of this study was the development of a method for the simultaneous determination of 3-monochloropropane-1,2-diol esters (3-MCPDEs) and glycidyl esters (GEs) in infant formula milk powder. Commercial infant formulas available on the Chinese market (n = 30) were analyzed for 3-MCPDEs and GEs by gas chromatography-mass spectrometry (GC-MS). Under the optimized conditions, 3-MCPDEs and GEs showed good linearity in the concentration range of 0.050?0.80 mg/L with correlation coefficient (R2) larger than 0.998. The mean recoveries from spiked samples were in the range of 81.4%?86.2% and 94.5%?101.1% with relative standard deviations (RSDs) ranging from 4.42% to 4.84% and from 4.46% to 6.12% for 3-MCPDEs and GEs, respectively. The limit of detection (LOD) of the proposed method was 30 μg/kg for both 3-MCPDEs and GEs. This method showed the advantages of high sensitivity, and accuracy, and could be suitable for the simultaneous detection of 3-MCPDEs and GEs in infant formula milk powder. In the 30 infant formula samples, levels of 3-MCPDEs and GEs ranged from 50.0 to 207.8 μg/kg and from 50.0 to 480.0 μg/kg with an average of 98.0 and 208.1 μg/kg, respectively.

Key words: isotope internal standard-gas chromatography-mass spectrometry, 3-monochloropropane-1,2-diol esters, glycidol esters, infant formula powder, quantitative determination

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