Abstract: Perfluorinated compounds (PFCs), a class of fluorine-containing hydrocarbon compounds, are widely used in food, pharmaceutical and agricultural industries for its relatively stable physicochemical properties. But its poor degradability could bring about unpredictable damages to the atmosphere, soil and even organisms. In this paper, the current pollution situation of PFCs in water, plants, fishery products, meat and eggs is summarized, and the interaction between PFCs and liver fatty acid binding protein (L-FABP), which interferes with lipid metabolism and consequently leads to obesity, insulin resistance, type 2 diabetes and hyperlipidemia is reviewed together with the binding characteristics of PFCs with L-FABP and the possible mechanisms for the bioaccumulation and hepatotoxicity of PFCs. It is of great significance to understand the distribution in vivo and physiological toxicity of PFCs. Thus, the binding of PFCs with nine types of FABPs needs further investigation.

Key words: perfluorinated compounds, food pollution, liver fatty acid binding protein, interaction