FOOD SCIENCE ›› 2020, Vol. 41 ›› Issue (13): 169-173.doi: 10.7506/spkx1002-6630-20190702-030

• Nutrition & Hygiene • Previous Articles     Next Articles

Hypoglycemic Effect of Sweet Corn Cob Polysaccharide on Diabetic Rats

MA Yongqiang, ZHANG Kai, WANG Xin, LU Xuechun, LIN Congyu   

  1. (1. College of Food Engineering, Harbin University of Commerce, Harbin 150076, China;2. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150080, China)
  • Online:2020-07-15 Published:2020-07-29

Abstract: We have previously prepared a polysaccharide from sweet corn cobs named SCP-80-1 and have demonstrated it to have a good hypoglycemic effect in vitro. In this study, we evaluated the hypoglycemic effect of SCP-80-1 on streptozotocin (STZ)-induced diabetic rats. The diabetic animals were administered intragastrically with SCP at doses of 100, 200 and 400 mg/kg mb or metformin at 200 mg/kg mb for 28 days. The fasting blood glucose, glucose tolerance, insulin content, blood lipids, visceral organ indices and pancreatic tissue sections were measured. The results showed that SCP-80-1 could decrease the fasting blood glucose level and postmeal blood glucose level, and improve the glucose tolerance of diabetic rats. It was also found that SCP-80-1 could improve blood lipid levels by reducing the levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol and increasing the level of high-density lipoprotein cholesterol. In addition, SCP-80-1 could reduce organ swelling to a certain extent, repair the damaged islet tissue, and increase the number of islet B cells. Therefore, SCP-80-1 can effectively regulate the blood glucose level of diabetic rats, improve glucose tolerance and repair the injured islet tissue, indicating that this polysaccharide is a natural hypoglycemic agent that is promising for application in the treatment of diabetes mellitus.

Key words: diabetes mellitus, sweet corn cob polysaccharide, hypoglycemia, blood lipid level, pancreatic tissue

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