FOOD SCIENCE ›› 2012, Vol. 33 ›› Issue (23): 323-326.

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Protective Effect of Polysaccharides from Pleurotus cornucopiae against Alcohol-Induced Acute Liver Injury in Mice

  

  • Received:2011-10-21 Revised:2012-11-20 Online:2012-12-15 Published:2012-12-12

Abstract: The present study investigated the protective effect of polysaccharides in hot water extract from Pleurotus cornucopiae (PCNP) on alcohol-induced acute liver injury in mice. Mice were randomly divided into blank control, alcohol-induced liver injury model, positive control and PCNP treatment (at doses of 100, 200 mg/(kg·d) and 400 mg/(kg·d) groups. After 30 consecutive days of intragastric administration, all the mice except for blank control group were given by gavage 50% alcohol at a dose of 12 mL/kg to induce acute liver injury. At 12 h after alcohol administration, all the mice in each group were killed by cervical dislocation and blood and liver were collected for the measurement of antioxidant indicators and pathological observation of liver tissue. Compared with the model group, PCNP administration resulted in a decrease in MDA content in the liver and the activities of AST, ALT in the serum, and an increase in the activities of SOD and CAT and GSH content in the liver of mice. In conclusion, PCNP can obviously improve pathological liver injury and protect against acute alcohol-induced liver injury in mice.

Key words: Pleurotus cornucopiae polysaccharides, acute liver injury, antioxidant status, serum, alcohol

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