FOOD SCIENCE

• Reviews • Previous Articles     Next Articles

Current Progress in the Understanding of the Mechanism of Prevention and Treatment of Lycium barbarum Polysaccharides on Type 2 Diabetes

XIA Hui1, TANG Huali1,2, PAN Jiaqi1, SUN Guiju1,*   

  1. 1. School of Public Health, Southeast University, Nanjing 210009, China;
    2. College of Life Science and Engineering, Chongqing Three Gorges University, Chongqing 404000, China
  • Online:2016-05-15 Published:2016-05-18

Abstract:

The present review summarizes therapeutic effects of Lycium barbarum polysaccharides (LBP) on type 2 diabetes.
Research indicated that LBP treatment could lower blood glucose and lipid levels, facilitate insulin secretion, attenuate
insulin resistance and increase insulin sensitivity. Furthermore, superoxide dismutase activity (SOD), malondialdehyde
(MDA) level, nitrogen monoxide (NO) content and other oxidative stress indicators could be significantly improved by LBP
administration. The mechanism may be associated with the improvement of pancreas islet function, such as upregulation
of insulin receptor substrate-1 and regulation of genes related to glycometabolism. LBP also has potential preventive and
therapeutic effects on diabetes complications.

Key words: Lycium barbarum polysaccharides, type 2 diabetes, blood glucose-lowering, blood lipid-lowering, insulin secretion, diabetes complications

CLC Number: