Effect of Buckwheat Chaff Extract on Serum Glucose and Lipid Profiles in Type 2 Diabetic Rats

Abstract

Abstract: Objective: To study the effect of buckwheat chaff extract (BCE) on serum glucose and lipid profiles in type 2 diabetic rats and the underlying mechanism. Methods: Type 2 diabetic rat models were established by intraperitoneal injection of streptozotocin (STZ) and feeding high-fat diet and divided into model control group and BCE treatment group. Fasting blood glucose (FBG) and euglycemic clamp technique were used to examine whether type 2 diabetes was successfully induced. All rats were fasted for 12 h after the last administration and blood was taken and assayed for free fatty acids (FFA), triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Results: STZ and high-fat diet induced type 2 diabetes in rats. BCE inhibited the increase of FBG, FFA, TC, TG, ALT and AST in the type 2 diabetic rats to different extents but resulted in a significant increase in serum HDL-C level. Conclusion: BCE improves insulin resistance (IR) through affecting serum glucose and serum lipid profiles in type 2 diabetic rats.

Key words: buckwheat, buckwheat chaff extract (BCE), type 2 diabetes, serum glucose and serum lipid profiles, insulin resistance

CLC Number:

References

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