FOOD SCIENCE ›› 2012, Vol. 33 ›› Issue (19): 363-368.

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Research Progress in Selenoproteins and Their Modulatory Effects on Macrophage Functions

  

  • Received:2011-09-01 Revised:2012-07-31 Online:2012-10-15 Published:2012-09-17
  • Contact: Na-Xin SUN E-mail:sunnx@126.com

Abstract: Selenium can exert its physiological functions in the form of selenoproteins in immune system. Macrophages play a pivotal role in immune regulation and bacterial defense. Recently, it has been found by using mice fed on selenium-rich diets, gene knockout mice and monoclonal antibody technology that selenoproteins have significant impact on redox status, migration and inflammatory responses of macrophages. In this article, we review recent research advances in the effects of selenoproteins on redox level, walk characteristics and inflammation in macrophages at the molecular level. This review suggests that selenoproteins may have complicated molecular modulation mechanisms and prospect medicinal benefits.

Key words: selenoprotein, macrophage, redox status

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