Construction of Lowly Toxic Liquid Crystals as Curcumin Delivery System

Abstract

Abstract: The phase diagram of oleyl polyoxyethylene (20) ether/butyl acetate/water was determined at 25 ℃, and the influence of the biosurfactant sodium deoxycholate (NaDC) on the phase behavior and rheological properties of the system was investigated. Furthermore, the protection and in vitro release behavior of curcumin in the liquid crystals were studied. Hexagonal and cubic crystals were found in the ternary system. When adding NaDC, the area of hexagonal phase became smaller and the cubic phase disappeared. All investigated samples followed a shear-thinning behavior under steady shear. The cubic crystals showed high elasticity with tan δ values less than 0.1, while the hexagonal crystals demonstrated typical visco-elasticity with tan δ values between 0.47 and 0.54. The characteristic relaxation time of the hexagonal crystals increased after adding NaDC. Curcumin could be protected by the liquid crystals against sun light. Surcumin solved in the liquid crystals exhibited slow release behavior. Moreover, the protection effect was enhanced and the equilibrium time of release was extended in NaDC containing systems.

Key words: liquid crystal, curcumin, rheological properties, sodium deoxycholate, carrier

CLC Number:

O647.2

zhong-Ni WANG Wu ZHOU Zhen LI. Construction of Lowly Toxic Liquid Crystals as Curcumin Delivery System[J]. FOOD SCIENCE, 2013, 34(1): 13-17.

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