Abstract: Studies were made on extracting total flavonoids from apple pericarps in this paper. Based on singer factor test, response surface method was used to study effects of extraction temperature, ethanol concentration, solid-liquid ratio and extraction time on extraction rate of total flavonoids from apple pericarps, and a second order quadratic equation for total flavonoids extraction was finally obtained. The results showed that the model was of great difference, and total flavonoids from apple pericarps was analyzed and predicted by the model. factors influencing the extraction of total flavonoids from the apple pericarps by the water bath method were in the order as follows: ethanol concentration＞extraction temperature＞solid/liquid ratio(g/mL)＞extraction time. the optimum extraction conditions of total flavonoids from apple pericarps were ethanol concentration 65%, extraction temperature 45℃, solid/liquid ratio(g/mL) 1:45, extraction time 210 minutes, the extraction rate of total flavonoids from apple pericarps was 3.52% under the optimal conditions.