Downregulation of PGC-1α and FoxO4 Expressions by Chicoric Acid in 3T3-L1 Preadipocytes

doi:10.7506/spkx1002-6630-201321059

Abstract

Abstract:

Chicoric acid, a naturally occurring polyphenolic compound, has been reported to have multiple bioactivities.
Our previous study indicated that chicoric acid induced the apoptosis of 3T3-L1 preadipocytes. PGC-1α and FoxO4 were
two important apoptotic proteins in preadipocytes. However, the impact and underlying mechanism of chicoric acid on
these proteins remain unknown. The purpose of this work was to investigate these issues. Our results revealed that chicoric
acid down-regulated the expressions of PGC-1α and FoxO4, and these effects were enhanced by the PI3K/Akt inhibitor
LY294002. These data suggested that the down-regulatory effect of chicoric acid on the expressions of PGC-1α and FoxO4
was achieved through PI3K/Akt signaling pathway.

Key words: chicoric acid；3T3-L1 preadipocytes；PI3K/Akt；PGC-1&alpha, ；FoxO4

CLC Number:

TS201.4

XIAO Hai-fang1,2，YUAN Li1，WANG Jing1，LIU Xue-bo1,*. Downregulation of PGC-1α and FoxO4 Expressions by Chicoric Acid in 3T3-L1 Preadipocytes[J]. FOOD SCIENCE, 2013, 34(21): 297-301.

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