FOOD SCIENCE ›› 2013, Vol. 34 ›› Issue (11): 45-48.doi: 10.7506/spkx1002-6630-201311011

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Synthesis and in vitro Anti-tumor Activity of Fatty Acid Derivatives of Ginsenoside Rg3

YE Hui1,2,ZHANG Bing1,2,JIANG Hai-wei1,2,CHENG Wen-juan1,2,DENG Ze-yuan1,2,HU Jiang-ning1,2,*   

  1. 1. State Key Laboratory of Food Science and Engineering, Nanchang University, Nanchang 330047, China;
    2. College of Life Science and Food Engineering, Nanchang University, Nanchang 330031, China
  • Received:2013-01-07 Revised:2013-05-09 Online:2013-06-15 Published:2013-06-03
  • Contact: HU Jiang-ning E-mail:yh881018106@yahoo.com.cn

Abstract:

The aim of this study was to synthesize fatty acid derivatives from ginsenoside Rg3. Esterified compounds were
prepared from the reaction of ginsenoside Rg3 and palmitoyl chloride with methylene dichloride as solvent and potassium
carbonate as acid-binding agent by stiring the mixture at 40 ℃ for 6 h. In addition, one major product was obtained by silica
gel column chromatography and its structure was characterized by UV, IR, HPLC/QTOF-MS and NMR. MTT method was
used to evaluate the mortality rate of MCF-7 cells after incubation with the product at different concentrations. The results
indicated that the proliferation of MCF-7 cells was inhibited by the derivative of gensinoside Rg3 in a dose- and timedependent
manner in the concentration range of 10-100 μg/mL. After incubation for 24, 48 h and 72 h, the IC50 was 146.68,
122.39 μg/mL and 101.95 μg/mL, respectively. These results suggest that this derivatized gensinoside Rg3 is a potential raw
material for pharmaceuticals.

Key words: ginsenoside Rg3, palmitoyl chloride, human breast cell lines

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