Mechanisms of Interaction between Probiotics and Intestinal Epithelial Cells and Immune Regulation

doi:10.7506/spkx1002-6630-201321077

Abstract

Abstract:

Probiotic colonization in the intestine by regulating signaling pathways such as NF-κB and MAPK to increase
or inhibit downstream pathways can change the physiology of the gastrointestinal tract, improve the micro-environment of
the gastrointestinal tract, and prevent and treat a variety of diseases, but its mechanism has not been fully understood. In this
article, the evidence about interaction between probiotics and intestinal epithelial cells, especially the emphasis on its regulation
of inflammatory signal pathways, stimulation of heat shock proteins, as well as the regulation of cell apoptosis, have
been reviewed, which will provide new theoretical basis for the diagnosis and treatment of intestinal diseases.

Key words: probiotics, intestinal epithelial cell, signal pathway, mechanism

CLC Number:

TS201

MENG Fei，WANG Chun-feng，YANG Gui-lian*. Mechanisms of Interaction between Probiotics and Intestinal Epithelial Cells and Immune Regulation[J]. FOOD SCIENCE, 2013, 34(21): 394-398.

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