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ACE2: a New Target for the Regulation of Renin-angiotensin System

GUANG Cui-e,JIANG Bo   

  1. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
  • Online:2013-06-15 Published:2013-06-03

Abstract:

Angiotensin converting enzyme 2 (ACE2) is a homologue of the human ACE. ACE2 counter-regulates the
effects of the classical ACE-Ang Ⅱ-angiotensin Ⅱ type 1 receptor (AT1R) axis via the function of the novel axis ACE2-
angiotensin-(1-7)-Mas receptor [ACE2-Ang-(1-7)-Mas] of the renin-angiotensin system (RAS). A chronic and sustained
imbalance between both axes may lead to pathophysiology of the cardiovascular, renal, pulmonary and central nervous
system. ACE2 agonist analogues are abundantly found in many natural plant resources.

Key words: angiotensin converting enzyme 2 (ACE2), analogues, xanthone