Research Progress in Immune Regulation of Bioactive Peptides on NF-κB

doi:10.7506/spkx1002-6630-201321075

Abstract

Abstract:

Nuclear factor-κB (NF-κB) has been reported to play an important role in immunity, inflammation and carcinogenesis
by regulating the expression of its target genes. Thus, NF-κB was recognized as a promising target for the prevention
and treatment of cancer and inflammation. Because bioactive peptides have many physiological functions and unique nutritional
properties, it can be widely used in the fields of functional foods and medicinal products. In this paper, the compositions,
structural characteristics and activation pathways of NF-κB are outlined. Recent research advances in the regulation
and therapeutic effects of bioactive peptides on NF-κB pathways are reviewed. Moreover, the future development prospects
of bioactive peptides are also proposed.

Key words: nuclear factor-&kappa, B (NF-&kappa, B)；bioactive peptide；regulatory mechanism；immune response

CLC Number:

R151

GONG Jian-miao，CHEN Qing-sen*，YAN Ya-li，PANG Guang-chang. Research Progress in Immune Regulation of Bioactive Peptides on NF-κB[J]. FOOD SCIENCE, 2013, 34(21): 379-388.

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