Effects of Pseudobulbus Cremastrae Seu Pleiones Polysaccharide on the Immune Regulation and the Inhibition of Tumor Growth in Sarcoma S180 Tumor-bearing Mice

Abstract

Abstract: Abstract: Objective To explore the Pseudobulbus cremastrae seu pleiones polysaccharide (PCSPP) on the immune regulation and the inhibition of tumor growth in sarcoma S180 tumor-bearing mice. Methods Lymphocyte proliferation ability and activity of phagocyte were determined by MTT and devour neutral red methods; the effects of PCSPP on inhibition of tumor growth, spleen index and thymus index in S180 tumor-bearing mice were evaluated through the experiment of tumor suppression in vivo; the effects of PCSPP on T lymphocyte subgroup and immune factor expressions were detected by flow cytometry and ELISA methods, respectively. Results PCSPP could enhance lymphocyte proliferation ability and activity of phagocyte; PCSPP could inhibit tumor growth and increase spleen index and thymus index in S180 tumor-bearing mice; meanwhile, PCSPP could also increase the levels of CD4+, CD8+ T cells in mice and elevate the CD4+/CD8+ ratio, IL-2, TNF-a and IFN-γ levels. Conclusion PCSPP has obvious tumor suppression effect and its inhibitory effect may be related to its improvement of immune ability.

Key words: Pseudobulbus cremastrae seu pleiones polysaccharide, sarcoma, immunity regulation, cytokines

CLC Number:

R285.5

Shuang JIANG. Effects of Pseudobulbus Cremastrae Seu Pleiones Polysaccharide on the Immune Regulation and the Inhibition of Tumor Growth in Sarcoma S180 Tumor-bearing Mice[J]. FOOD SCIENCE, 0, (): 0-0.

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