Abstract: This work intended to optimize recipes for high-fiber chewable tablets which made mainly by Pleurotus geesteranus mycelia degraded wheat bran dietary fiber (DF). The experiments were conducted on auxiliary forced filling technique applied to powder direct tabletting, and response surface methodology used to select optimal recipe with variable factors such as tablet weight, disintegration time, hardness and friability. The in vitro antioxidant properties of chewable tablets were compared. The results showed that the optimal recipe of chewable tablets consisted of 64% DF, 34% ultra-fine okra powder and 2% magnesium stearate, and tablet surface revealed smooth with uniformity in color and moderate in texture. The results indicated that the chewable tablets possessed antioxidative capacity in aspects of anti-lipoperoxidation and scavenging free hydroxyl radicals, the IC50 value of hydroxyl radical clearance was 20mg?mL-1 and the IC50 value of lipid peroxidation inhibition rate was 8mg?mL-1 . By using direct tabletting auxiliary forced filling, this work intends to study the recipe of high-fiber chewable tablets and its in vitro antioxidant capacity, as well as to provide scientific data for production.

Key words: chewable tablet, wheat bran dietary fiber, recipe optimization, in vitro antioxidant