Abstract: Wheat bran dietary fiber chewable tablets were produced by direct compression from dietary fiber (DF) rich wheat bran fermented by Pleurotus geesteranus with magnesium stearate and ultra-fine okra powder and added. The formulation of chewable tablets was optimized by response surface methodology with mass deviation, disintegration time, hardness and friability as responses. Meanwhile, the in vitro antioxidant properties of chewable tablets were evaluated. The results showed that the optimal formulation consisted of 64% fermented wheat bran, 34% ultra-fine okra powder and 2% magnesium stearate. The tablets produced revealed a smooth surface with uniform color and moderate hardness. The chewable tablets possessed strong antioxidant capacity in terms of anti-lipoperoxidation and hydroxyl radical scavenging capacity with IC50 values of 8 and 20 mg/mL, respectively. The formulation optimization antioxidant activity evaluation of wheat bran dietary fiber chewable tablets can provide theoretical support for the nutritional and functional value of the product

Key words: chewable tablet, wheat bran dietary fiber, recipe optimization, in vitro antioxidant activity