Research Process of Ca2+ Signaling Pathway Regulating Muscle Fiber Type Transformation

Abstract

Abstract: Abstract：Ca2+ signaling pathway includes two Ca2+-dependent signaling pathways, calcineurin(CaN) and calmodulin kinase(CaMK), which are all activated to promote the transition from fast muscle fibers to slow muscle fibers. This review summarized the structure of CaN and CaMK, the mechanism of action and related research of the Ca2+ signaling pathway, the main factors affecting the regulation of Ca2+ signaling pathway, the role of Ca2+ signaling pathway in the transformation of muscle fiber type and the relationship with meat quality. Forecast the future direction of research, it will provide theoretical basis for improve meat quality through genetic and nutritional measures.

Key words: CaN pathway, CaMK pathway, muscle fiber type transformation, meat quality

CLC Number:

TS251.1

Pu-Xin HOU. Research Process of Ca2+ Signaling Pathway Regulating Muscle Fiber Type Transformation[J]. FOOD SCIENCE, 0, (): 0-0.

References

[1]尹丽卿.不同饲养方式下苏尼特羊肌纤维特性和MyHC基因对肉质的影响[D]. 内蒙古农业大学, 2016. [2]苏琳.巴美肉羊肌纤维特性、糖酵解潜力对羊肉品质的影响和MyHC表达量分析[D]. 内蒙古农业大学, 2015. [3]郭秋平, 文超越, 王文龙, 等.肌纤维类型转化的分子信号通路及其营养调控进展[J].动物营养学报, 2017, 29(6):1836-1842 [4]袁媛, 刘月光, 史新娥, 等.调控骨骼肌纤维类型转化的信号通路[J].中国生物化学与分子生物学报, 2010, 26(9):796-801 [5]Allen D L, Leinwand L A.Intracellular calcium and myosin isoform transitionsCalcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter.[J].Journal of Biological Chemistry, 2002, 277(47):45323-30 [6]Klee C B, Ren H, Wang X.Regulation of the calmodulin-stimulated protein phosphatase,calcineurin[J].J.biol.chem, 1998, 273(22):13367-70 [7]Molkentin J D, Lu J R, Antos C L, et al.A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy[J].Cell, 1998, 93(2):215- [8]刘志云, 魏美芳.钙调神经磷酸酶在高血压心肌肥厚中的表达[J].中国当代医药, 2010, 17(29):6-8 [9]Tavi P, Allen D G, Niemel? P, et al.Calmodulin kinase modulates Ca2+ release in mouse skeletal muscle[J].J Physiol, 2003, 551(1):5-12 [10]Wu H, Kanatous S B, Thurmond F A, et al.Regulation of Mitochondrial Biogenesis in Skeletal Muscle by CaMK[J].Science, 2002, 296(5566):349-352 [11]Jain J, Mccafffrey P G, Miner Z, et al.The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun[J].Nature, 1993, 365(6444):352-5 [12]Schreiber, Stuart L, Crabtree, et al.The mechanism of action of cyclosporin A and FK506[J].Clinical Immunology & Immunopathology, 1996, 80(3 Pt 2):S40- [13]Chin E R, Olson E N, Richardson J A, et al.A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type[J].Genes Dev, 1998, 12(16):2499-2509 [14]Naya F J, Mercer B, Shelton J, et al.Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo[J].Journal of Biological Chemistry, 2000, 275(7):4545-4548 [15]Miyazaki M, Hitomi Y, Kizaki T, et al.Calcineurin-mediated slow-type fiber expression and growth in reloading condition[J].Med Sci Sports Exerc, 2006, 38(6):1065-1072 [16]Mu X, Brown L D, Liu Y, et al.Roles of the calcineurin and CaMK signaling pathways in fast-to-slow fiber type transformation of cultured adult mouse skeletal muscle fibers[J].Physiological Genomics, 2007, 30(3):300- [17]Yuan Y, Shi X E, Liu Y G, et al.FoxO1 regulates muscle fiber-type specification and inhibits calcineurin signaling during C2C12 myoblast differentiation[J].Molecular & Cellular Biochemistry, 2011, 348(1-2):77-87 [18]Parsons S A, Wilkins B J, Bueno O F, et al.Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice[J].Molecular & Cellular Biology, 2003, 23(12):4331-43 [19]Chakkalakal J V, Harrison M A, Carbonetto S, et al.Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice[J].Human Molecular Genetics, 2004, 13(4):379- [20]王建华.肌纤维类型转化通路CaN/NFAT相关基因的表达分析及CAML基因的分离鉴定[D]. 华中农业大学, 2010. [21]束婧婷, 宋迟, 徐文娟, 等.信号通路相关基因在鸭发育早期骨骼肌中的同步表达及其与肌纤维性状相关性[J].中国农业科学, 2015, 48(6):1195-1204 [22]张凯, 高原, 苏艳红.骨骼肌纤维类型转换的分子信号机制[J].湖北体育科技, 2013, 32(4):314-317 [23]Liu Y, Shen T, Randall W R, et al.Signaling pathways in activity-dependent fiber type plasticity in adult skeletal muscle[J].J Muscle Res Cell Motil, 2005, 26(1):13-21 [24]Swoap S J, Hunter R B, Stevenson E J, et al.The calcineurin-NFAT pathway and muscle fiber-type gene expression[J].Am J Physiol Cell Physiol, 2000, 279(4):915-24 [25]Allen D L, Sartorius C A, Sycuro L K, et al.Different pathways regulate expression of the skeletal myosin heavy chain genes[J].Journal of Biological Chemistry, 2001, 276(47):43524-33 [26]Smith J A, Kohn T A, Chetty A K, et al.CaMK activation during exercise is required for histone hyperacetylation and MEF2A binding at the MEF2 site on the Glut4 gene[J].American Journal of Physiology, 2008, 295(1):698-704 [27]Ou N, Liu G, Jiang F, et al.Effect of chronic electrical stimulation on transformation of myosin heavy chain isoforms in differentiated C2C12 cells[J]. Journal of Third Military Medical University, 2012.[J].Physiological Genomics, 2007, 30(3):300- [28]Grondard C, Biondi O, Pariset C, et al.Exercise‐induced modulation of calcineurin activity parallels the time course of myofibre transitions[J].Journal of Cellular Physiology, 2008, 214(1):126-35 [29]Mckinsey T A, Zhang C L, Lu J, et al.Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation[J].Nature, 2000, 408(6808):106- [30]Flück M, Waxham M N, Hamilton M T, et al.Skeletal muscle Ca2+-independent kinase activity,increases during either hypertrophy or running[J].Journal of Applied Physiology, 2000, 88(1):352- [31]Kao H Y, Verdel A, Tsai C C, et al.Mechanism for nucleocytoplasmic shuttling of histone deacetylase[J].Journal of Biological Chemistry, 2001, 276(50):47496-507 [32]Akimoto T, Ribar T J, Williams R S, et al.Skeletal muscle adaptation in response to voluntary running in Ca2+calmodulin-dependent protein kinase IV-deficient mice[J].American Journal of Physiology Cell Physiology, 2004, 287(5):C1311- [33]Wright D C, Hucker K A, Holloszy J O, et al.Ca2+ and AMPK both mediate stimulation of glucose transport by muscle contractions[J].Diabetes, 2004, 53(2):330- [34]Hudson M B, Price S R.Calcineurin: a poorly understood regulator of muscle mass[J].International Journal of Biochemistry & Cell Biology, 2013, 45(10):2173-2178 [35]Musarò A, Mccullagh K J, Naya F J, et al.IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1[J].Nature, 1999, 400(6744):581- [36]Serrano A L, Murgia M, Pallafacchina G, et al.Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth[J].Proceedings of the National Academy of Sciences of the United States of America, 2001, 98(23):13108-13113 [37]廖八根, 徐勇, 薛耀明.钙调神经磷酸酶在耐力运动大鼠骨骼肌纤维类型和大小转变中的作用[J].中国运动医学杂志, 2008, 27(5):551-555 [38]吴金富.Ca2+/CaN途径在悬吊再负荷大鼠肌纤维类型转化中的作用[D]. 北京体育大学, 2010. [39]尹丽琴, 李范玲, 汤长发, 等.不同强度运动对骨骼肌纤维亚型转化及信号通路的影响[J].中国应用生理学杂志, 2017, 33(4):360-364 [40]Passier R, Zeng H, Frey N, et al.CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo[J].Journal of Clinical Investigation, 2000, 105(10):1395-406 [41]Rose A J, Kiens B, Richter E A.Ca2+-calmodulin-dependent protein kinase expression and signaling in skeletal muscle during exercise[J].Journal of Physiology, 2006, 574(Pt 3):889-903 [42]Sharlo C A, Lomonosova Y N, Turtikova O V, et al.The Role of GSK-3 Phosphorylation in the Regulation of Slow Myosin Expression in Soleus Muscle during Functional Unloading[J].Biochemistry Supplement, 2018, 12(1):85-91 [43]Fajardo V A, Rietze B A, Chambers P J, et al.Effects of sarcolipin deletion on skeletal muscle adaptive responses to functional overload and unload.[J]. American Journal of Physiology Cell Physiology, 2017:ajpcell.00291.2016.DOI:10.1152/ajpcell.00291.2016[J].American Journal of Physiology Cell Physiology, 2007, :- [44]Lomonosova Y N, Turtikova O V, Shenkman B S.Reduced expression of MyHC slow isoform in rat soleus during unloading is accompanied by alterations of endogenous inhibitors of calcineurinNFAT signaling pathway[J].Journal of Muscle Research & Cell Motility, 2015, 37(1-2):7-16 [45]Crabtree G R.Generic signals and specific outcomes: signaling through Ca2+,calcineurin,and NF-AT[J].Cell, 1999, 96(5):611-614 [46]Rao A, Luo C, Hogan P G.Transcription factors of the NFAT family: regulation and function[J].Annual Review of Immunology, 1997, 15(15):707-747 [47]李范玲.运动对大鼠骨骼肌纤维类型的影响以及CaN/NFAT信号机制初步研究[D]. 湖南师范大学, 2011. [48]Mccullagh K J, Calabria E, Pallafacchina G, et al.NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching[J].Proceedings of the National Academy of Sciences of the United States of America, 2004, 101(29):10590- [49]Yamaguchi T, Omori M, Tanaka N, et al.Distinct and additive effects of sodium bicarbonate and continuous mild heat stress on fiber type shift via calcineurinNFAT pathway in human skeletal myoblasts[J].Am J Physiol Cell Physiol, 2013, 305(3):C323-C333 [50]Schiaffino S.Fibre types in skeletal muscle: a personal account[J].Acta Physiologica, 2010, 199(4):451-463 [51]Jr V I, Aguiar A F, de Souza R W, et al.NFAT Isoforms Regulate Muscle Fiber Type Transition without Altering CaN during Aerobic Training[J].International Journal of Sports Medicine, 2013, 34(10):861-867 [52]Black B L, Olson E N.Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins[J].Annu Rev Cell Dev Biol, 1998, 14(1):167-196 [53]Wu H, Naya F J, Mckinsey T A, et al.MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type[J].Embo Journal, 2000, 19(9):1963-1973 [54]贾安峰, 冯京海, 张敏红.调控骨骼肌肌纤维类型转化的因素及机制[J].动物营养学报, 2014, 26(5):1151-1156 [55]Potthoff M J, Wu H, Arnold M A, et al.Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers[J].Journal of Clinical Investigation, 2007, 117(9):2459-2467 [56]Hennebry A, Berry C, Siriett V, et al.Myostatin regulates fiber-type composition of skeletal muscle by regulating MEF2 and MyoD gene expression[J].American Journal of Physiology Cell Physiology, 2009, 296(3):C525- [57]尹靖东.动物肌肉生物学与肉品科学[M]. 中国农业大学出版社, 2011. [58]Leseigneurmeynier A, Gandemer G.Lipid composition of pork muscle in relation to the metabolic type of the fibres[J].Meat Science, 1991, 29(3):229-241 [59]Offer G.Modelling of the formation of pale,soft and exudative meat: Effects of chilling regime and rate and extent of glycolysis[J].Meat Science, 1991, 30(2):157-84 [60]苏琳, 辛雪, 刘树军, 等.苏尼特羊肉肌纤维特性与肉质相关性研究[J].食品科学, 2014, 35(7):7-11 [61]Liu W, Chen G, Li F, et al.Calcineurin-NFAT Signaling and Neurotrophins Control Transformation of Myosin Heavy Chain Isoforms in Rat Soleus Muscle in Response to Aerobic Treadmill Training[J].Journal of Sports Science & Medicine, 2014, 13(4):934-44