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• Nutrition and Hygiene •     Next Articles

Anthocyanins from fruit of Nitraria tangutorun Bobr. improve nonalcoholic fatty liver injury induced by high-fat diet in mice

LI Bing 2,ZHANG Jin2,Cui QinLi2   

  • Received:2018-09-14 Revised:2019-06-05 Online:2019-10-15 Published:2019-10-25
  • Contact: LI Bing E-mail:libing.x@foxmail.com

Abstract: Abstract: Objective To investigate the effects of anthocyanins from Nitraria tangutorun Bobr. fruit on nonalcoholic fatty liver injury induced by high-fat diet (HFD) in C57BL/6J mice and its mechanism. Methods Male C57BL/6J mice were randomly divided into control group, high fat model group and anthocyanins from N. tangutorun Bobr. administration group, continuous feeding for 14 weeks. The body weight, abdominal fat, body fat index, visceral fat weight, body length and Lee's index were measured in each mice. The serum samples were collected to detect routine physiological index such as glutamic-oxalacetic transaminease(AST), glutamic-pyruvic transaminase(ALT), total cholesterol (TC), total triglyceride (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL). The liver samples were collected to detect oxidative stress related indicators such as malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the expression level of liver lipid metabolism related proteins, such as acetyl coenzyme A carboxylase (ACC), liver X receptor (LXR-alpha), fatty acid transposition enzyme (CD36) and peroxidase activated receptor-alpha (PPAR-alpha). Results Compared with the high-fat model group, the anthocyanins from N. tangutorun Bobr. significantly reduced the body weight, abdominal fat, lipoprotein index, visceral fat weight and Lee's index of high-fat mice. At the same time, the AST, ALT, TC, TG, LDL contents in serum of high-fat mice were significantly reduced and HDL content were significantly increased. In addition, the anthocyanins from N. tangutorun Bobr. significantly decreased the content of MDA and the activity of SOD and increased the activity of GSH-Px in liver tissue, significantly decreased the expression of ACC, LXR-α and CD36 in liver tissue, and upregulated the expression of PPAR-α. Conclusion The anthocyanins from Nitraria tangutorun Bobr. ameliorated HFD-induced NAFLD in mice by regulating hepatocyte oxidative stress and lipid metabolism.

Key words: Key words: Anthocyanins from Nitraria tangutorun Bobr., NAFLD, Oxidative stress, Lipid metabolism

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