A Review of Functional Components and Activities in    Loquat (Eriobotrya japonica Lindl.)

Abstract

Abstract: Abstract: As a traditional Chinese medicine and food homologous plant, Eriobotrya japonica has always played a significant part of human life. The pulp of fruit is edible and tastes sweet and acidic. The leaves have been used as a folk medicine for treatment of coughs, pulmonary heat in china since Wei Jin and the Northern and Southern dynasties, and today it still plays an irreplaceable role in treating cough with Pipa syrup and Confection. With the scientific research progressing, the type,content and bioactivity of functional components in loquat leaves, flowers, fruits and seeds are gradually revealed. This paper mainly reviews the functional components, functionalities and their changes in recent years, in order t to provide theoretical guidance for the development and utilization of loquat medicine and health care products.

Key words: Key words: Eriobotrya Japonica, Triterpenes, Flavonoids, Amygdalin, Antitussive, Anti-oxidation, Anti-tumor

CLC Number:

S667.3

Li-Li noLIU Zhou-Min LU. A Review of Functional Components and Activities in Loquat (Eriobotrya japonica Lindl.)[J]. FOOD SCIENCE, 0, (): 0-0.

References

[1]邱武凌, 章恢志.中国果树志: 龙眼枇杷卷[M]. 北京：中国林业出版社，1996: 5-44. [2]胡又厘, 林顺权.世界枇杷研究与生产[J].世界农业, 2002, (1):18-20 [3]李檐堂，霍宇航，孟瑶瑶，鲁周民.安康地区 10 个日本引种枇杷果实品质比较. 食品科学.http://kns.cnki.net/kcms/detail/11.2206.TS.20180622.1028.066.html. [4]张玉, 王建清.枇杷的营养及功能成分研究进展[J].食品科学, 2005, (09):584-586 [5]国家药典委员会.中华人民共和国药典（四部）[S].北京：化学工业出版社.2015:204-205, 201-202.[2018-12-15, 2018-01-20]. https://www.drugfuture.com/Pharmacopoeia/CP2015-1/204-205, 201-202.pdf [6]药物在线.药品标准查询数据库:枇杷[DB/OL]. [2018-01-19]. https://www.drugfuture.com/standard/. [7]汪世新.21世纪高等院校教材有机化学[Z]. 上海教育出版社, 2004:385. [8]鞠建华, 周亮, 林耕, 等.枇杷叶中三萜酸类成分及其抗炎、镇咳活性研究[J].中国药学杂志, 2003, 38(10):752-757 [9]Tommasi N D, Simone F D, Cirino G, et al.Hypoglycemic effects of sesquiterpene glycosides and polyhydroxylated triterpenoids of Eriobotrya japonica[J].Planta Medica, 1991, 57(05):414-416 [10]吕寒, 罗美红, 李维林.枇杷叶中三萜类成分分离及降血糖活性研究[C]//中国化学会天然有机化学学术会议:2012. [11]李继杨, 谢晓梅, 李倩文, 等.枇杷不同器官及不同物候4种三萜酸含量的动态变化[J].中国中药杂志, 2015, (05):875-880 [12]成丽, 刘燕, 陈凌亚, 等.枇杷花三萜皂甙成分的研究[J].华西医科大学学报, 2001, (02):283-285 [13]陈欢, 陈光, 任红梅, 等.枇杷叶中三萜类成分的研究[J].北京化工大学学报(自然科学版), 2012, (03):40-45 [14]李琪, 张宏, 黄春萍, 等.枇杷花化学成分及抗菌抗肿瘤活性研究[J].西南农业学报, 2014, (02):739-742 [15]Kikuchi T, Akazawa H, Tabata K, et al.O-(E)-p-coumaroyl tormentic acid from Eriobotrya japonica leaves induces caspase-dependent apoptotic cell death in human leukemia cell line[J].Chem Pharm Bull (Tokyo), 2011, 59(3):378-381 [16]Rollinger J M, Kratschmar D V, Schuster D, et al.Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches[J].Bioorganic & Medicinal Chemistry, 2010, 18(4):1507-1515 [17]Ito H, Kobayashi E, Li S, et al.Antitumor Activity of Compounds Isolated from Leaves ofEriobotrya japonica[J].Journal of Agricultural and Food Chemistry, 2002, 50(8):2400-2403 [18]Ito H, Kobayashi E, Li S, et al.Megastigmane Glycosides and an Acylated Triterpenoid fromEriobotryajaponica[J].Journal of Natural Products, 2001, 64(6):737-740 [19]Tan B, Yang L, Huang Y, et al.Bioactive triterpenoids from the leaves of Eriobotrya japonica as the natural PDE4 inhibitors[J].Natural Product Research, 2017, 31(24):2836-2841 [20]Niculescu M, Bercea I, Niculescu L, et al.Biological activities of Loquat[J].Annals of the University of Craiova - Agriculture, Montanology, Cadastre Series, 2018, (48):21-25 [21]洪燕萍, 黄素华, 林顺权.11种枇杷属植物叶片三萜酸含量测定: 第五届全国枇杷学术研讨会, 中国四川石棉, 2011[C]. [22]高锦明.植物化学.第2版[Z]. 北京:科学出版社, 2012:141. [23]林素英, 谢文燕, 何松涛, 等.不同品种枇杷果实酚类物质及其抗氧化活性分析[J].食品工业科技, 2016, (18):149-152 [24]张文娜, 李鲜, 孙崇德, 等.枇杷酚类物质及其生物活性研究进展[J].食品与药品, 2015, 17(02):123-128 [25]Zhang W, Zhao X, Sun C, et al.Phenolic composition from different loquat (Eriobotrya japonica Lindl) cultivars grown in China and their antioxidant properties[J].Molecules (Basel, Switzerland), 2015, 20(1):542-555 [26]Xu H, Li X, Chen J.Comparison of phenolic compound contents and antioxidant capacities of loquat (Eriobotrya japonica Lindl) fruits[J].Food Science and Biotechnology, 2014, 23(6):2013-2020 [27] Nabavi, S F, Nabavi, S M, Hajizadeh Moghaddam, A H, et al.Antihypoxic, nephroprotective and antioxidant properties of hydro-alcoholic extract of loquat flowers [J].Progress in Nutrition, 2015, 17(3):255-261 [28]陈业高.植物化学成分[Z]. 化学工业出版社化学与应用化学出版中心, 2004:158+168. [29]张丽华, 杨生婷, 徐怀德, 等.枇杷花香气成分固相微萃取GC-MS分析研究[J].食品科技, 2008, (03):108-110 [30]闫永芳.枇杷花主要营养成分、酚类物质及其干燥工艺研究[D]. 浙江大学, 2012:18-39. [31]Hong Y P, Lin B S, Ca H Y, et al.Chemical Constituent and Antimicrobial Activity of Essential Oil from Fragrant Loquat and Common Loquat[J].Applied Mechanics and Materials, 2011, 138-139:974-980 [32]李长虹, 秦小梅, 张璐璐, 等.枇杷核挥发油化学成分及体外抗氧化活性研究[J].华中师范大学学报(自然科学版),, 2014, (01):58-61 [33]陈飞平, 周家华, 常虹, 等.枇杷核成分、功效及开发利用研究进展[J].食品科学, 2012, (17):336-340 [34]林国荣.枇杷核苦杏仁苷的醇提工艺及其药效学研究[J].现代农业科技, 2007, (18):7-9 [35]Wu H, Cao C, Zhou C.Determination of amygdalin in the fruit of Eriobotrya japonica Lindl by high performance liquid chromatography[J].Biomedical Research, 2017, 28(20):8827-8831 [36]林国荣, 沈高杨, 陈剑锋.HPLC法测定枇杷核中苦杏仁苷含量[J].海峡药学, 2007, (01):41-42 [37]张娜, 吴绍康, 沈先荣, 等.枇杷叶水提物祛痰止咳及抗炎作用研究[J].中华中医药学刊, 2014, (09):2175-2177 [38]陈晓芳.枇杷花醇提物镇咳、平喘、祛痰作用及其机制研究[D]. 苏州大学, 2011:15-49. [39]Zhang J, Li Y, Chen S, et al.Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae[J].International Journal of Molecular Sciences, 2015, 16(2):2913-2941 [40]葛金芳, 李俊, 姚宏伟, 等.枇杷叶三萜酸的抗炎作用[J].安徽医科大学学报, 2007, (02):174-178 [41]葛金芳.枇杷叶三萜酸的抗炎免疫作用及对慢性支气管炎的治疗作用与机制研究[D]. 安徽医科大学, 2004:16-96. [42]Takuma D, Guangchen S, Yokota J, et al.Effect of Eriobotrya japonica seed extract on 5-fluorouracil-induced mucositis in hamsters[J].Biol Pharm Bull, 2008, 31(2):250-254 [43]Yang Y, Huang Y, Huang C, et al.Antifibrosis effects of triterpene acids of Eriobotrya japonica (Thunb) Lindlleaf in a rat model of bleomycin‐induced pulmonary fibrosis[J].Journal of Pharmacy and Pharmacology, 2012, 64(12):1751-1760 [44]蒋企洲, 欧瑜, 何执中.枇杷叶黄酮对油脂的抗氧化性能研究[J].医学综述, 2008, 14(10):1583-1585 [45]Delfanian M, Kenari R E, Sahari M A.Evaluation of antioxidant activity of loquat fruit (Eriobotrya japonica lindl) skin and the feasibility of their application to improve the oxidative stability of soybean oil[J].Journal of Food Science and Technology, 2016, 53(5):2244-2252 [46]王建超.枇杷叶多酚提取、纯化及其抗氧化、抑菌活性研究[D]. 福建农林大学, 2015:47-60. [47]许丽璇.枇杷叶黄酮的提取及对小鼠的抗氧化作用[J].西北农业学报, 2013, (03):23-28 [48]季晨怡, 郭瑞昕.枇杷核中黄酮类物质的提取与清除自由基效果的研究[J].广东化工, 2016, (02):17-18 [49]Tan H, Sonam T, Shimizu K.The Potential of Triterpenoids from Loquat Leaves (Eriobotrya japonica) for Prevention and Treatment of Skin Disorder[J].International Journal of Molecular Sciences, 2017, 18(5):1030-1030 [50]肖新生, 林倩英.枇杷叶提取物抑菌作用研究[J].现代食品科技, 2010, 26(1):59-62 [51]Onogawa M, Sun G, Takuma D, et al.Animal studies supporting the inhibition of mast cell activation by Eriobotrya japonica seed extract[J].Journal of Pharmacy and Pharmacology, 2009, 61(2):237-241 [52]Wu S, Zhang N, Shen X, et al.Preparation of total flavonoids from loquat flower and its protective effect on acute alcohol-induced liver injury in mice[J].Journal of Food and Drug Analysis, 2015, 23(1):136-143 [53]何玉琴, 林标声, 黄素华, 等.枇杷叶提取物对人工感染IBV生化指标及抗体影响[J].龙岩学院学报, 2013, (05):59-62 [54]国外医学中医中药分册编辑部.枇杷核提取物改善肝纤维化的作用(1):引起肝损害的物质对改善肝纤维化作用的影响[J].国外医学(中医中药分册), 2004, (02):124-124 [55]Ito H, Kobayashi E, Takamatsu Y, et al.Polyphenols from Eriobotrya japonica and their cytotoxicity against human oral tumor cell lines[J].Chem Pharm Bull (Tokyo), 2000, 48(5):687-693 [56]Kim M, You M, Rhuy D, et al.Loquat (Eriobotrya japonica) extracts suppress the adhesion,migration and invasion of human breast cancer cell line[J].Nutrition Research and Practice, 2009, 3(4):259-259 [57]Lu Q, Zhang X, Yang J, et al.Triterpenoid-rich loquat leaf extract induces growth inhibition and apoptosis of pancreatic cancer cells through altering key flux ratios of glucose metabolism[J].Metabolomics, 2017, 13(4):1-10 [58]李琪.枇杷花化学成分及生物活性的研究[D]. 四川师范大学, 2009:61-81. [59]Uto T, Sakamoto A, Tung N, et al.Anti-Proliferative Activities and Apoptosis Induction by Triterpenes Derived from Eriobotrya japonica in Human Leukemia Cell Lines[J].International Journal of Molecular Sciences, 2013, 14(2):4106-4120 [60]Zar P P K, Satoshi Y, Kozue S, et al.In vitro anticancer activity of loquat tea by inducing apoptosis in human leukemia cells[J].Journal of the Agricultural Chemical Society of Japan, 2014, 78(10):1731-1737 [61]Shih C, Ciou J, Lin C, et al.Cell Suspension Culture of Eriobotrya japonica Regulates the Diabetic and Hyperlipidemic Signs of High-Fat-Fed Mice[J].Molecules, 2013, 18(3):2726-2753 [62]Shafi S, Tabassum.N. Antidiabetic and hypolipidemic activities of ethanolic extract of eriobotrya japoica fruits in alloxan induced[J].International Journal of Pharmaceutical, Chemical and Biological science, 2013, 2(3):398-405 [63]吕寒, 习超鹏, 陈剑, 等.不同生长季节枇杷叶中三萜酸成分的含量变化[J].中国中药杂志, 2009, (18):2353-2355 [64]吴月娴, 吕寒, 简暾昱, 等.不同类型枇杷叶三萜酸类成分含量及降糖活性的比较[J].植物资源与环境学报, 2017, (04):101-103 [65]叶广亿, 李书渊, 陈艳芬, 等.枇杷叶不同提取物的止咳化痰平喘作用比较研究[J].中药药理与临床, 2013, (02):100-102 [66]Wu Y, Jian T, Lv H, et al.Antitussive and expectorant properties of growing and fallen leaves of loquat ( Eriobotrya japonica )[J].Revista Brasileira de Farmacognosia, 2018, 28(2):239-242 [67]付晓丹, 汤春丰, 刘壤莲, 等.枇杷叶黄酮提取物的抗氧化作用研究[J].食品工业科技, 2015, 36(1):135-139 [68]芦艳, 鲁周民, 樊美丽.枇杷花不同花期醇提物抗氧化活性的比较[J].现代食品科技, 2013, (09):2141-2146 [69]闫永芳, 孙钧, 孟天真, 等.枇杷花提取物抗氧化活性研究[J].食品工业科技, 2012, (01):122-124 [70]陈翔, 郑士华, 王喜周, 等.太平白枇杷花主要有效成分检测及制作工艺[J].浙江农业科学, 2018, (02):168-170 [71]Delfanian M, Kenari R E, Sahari M A.Influence of extraction techniques on antioxidant properties and bioactive compounds of loquat fruit (Eriobotrya japonica Lindl) skin and pulp extracts[J].Food Science & Nutrition, 2015, 3(3):179-187 [72]赵静.枇杷核苦杏仁苷提取、纯化及其抗氧化活性研究[D]. 南京农业大学, 2010:26-31. [73] Badenes, M.L., Blasco, M., Naval, M. M.. Loquat: progress and expectations[C]//R. Lo Bianco J.Janik . Proceedings of the Fourth International Symposium of Loquat. 2015 Acta Horticulturae. Palermo Italy, 2015:19-24.

A Review of Functional Components and Activities in Loquat (Eriobotrya japonica Lindl.)

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