Abstract: Abstract: The effects of wheat peptides on oxidative damage and antioxidant indexes in serum and liver tissues of ethanol-injured mice were researched to preliminary study the antioxidant function of wheat peptides on acute alcoholism mice. Healthy male ICR mice were randomly divided into five groups by weight: blank control group, model control group, and wheat peptides with low, medium and high intervention dose group (0.4 g/kg bw, 0.8 g/kg bw, 1.6 g/kg bw), and gavaged for 30 days. After the last lavage, model control group and three dose groups were gavaged 50% anhydrous ethanol lasting 16 hours (12 ml/kg bw), and blank group was not processed; The total superoxide dismutase (T-SOD) activity, reduced glutathione (GSH), malondialdehyde (MDA) and protein carbonyl (PC) in serum and liver of mice were determined after 6 hours. The results showed that: compared with the model control group, the activity of T-SOD in mice liver was significantly increased in each dose of wheat peptide group (P < 0.01). In the wheat peptide low dose group, the content of GSH in serum and liver of mice was significantly increased (P < 0.05, P < 0.01), and the content of PC in liver was significantly decreased (P < 0.05). The wheat peptide high dose group could significantly reduce the content of MDA in mice serum (P < 0.05). These results suggest that wheat peptides can enhance the antioxidant capacity in mice with acute alcoholism and have a protective effect on acute alcoholic liver injury in mice.

Key words: Keywords: Wheat peptides, Acute alcoholism, Alcoholic liver injury, Oxidative damage, antioxidant