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Progress of nanoparticles in lateral flow immunochromatographic strip

wang shujuan2,Ma-Lan 2, 2,Cheng-Chao DINGDONG Qing-Li 2, 2,   

  • Received:2018-08-20 Revised:2019-05-06 Online:2019-09-15 Published:2019-09-23

Abstract: Lateral flow immunoassay (LFIA) which combine the excellent separation ability of chromatography with the high specificity and sensitivity of conventional immunoassay, has served as an ideal platform for quantitative and sensitive on-site sensing, playing a significant role in food safety. In LFIA,the labelis one of the key points that affect the sensitivity. At present, the detection performance of LFIA is mainly enhanced by using nanoparticles. The colored (e.g., colloidal gold, carbon, and colloidal selenium NPs), luminescent (e.g., quantum dots, up-converting phosphor NPs, and dye-doped NPs), and magnetic NPs are integrated into membrane-based LFIA.This paper was aimed to summarize the recent advances in the nanoparticle-based lateral flow immunochromatography , with the improvement of their analytical performance with various types of nanoparticles detailedly analyzed so as to facilitate our screening of suitable ones while designing LFIA for specific aims.

Key words: nanoparticle, lateral flow immunoassay, food security applications

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