FOOD SCIENCE ›› 2019, Vol. 40 ›› Issue (17): 348-356.doi: 10.7506/spkx1002-6630-20180819-194

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Recent Progress on Nanoparticles in Lateral Flow Immunochromatographic Strip

TIAN Yachen, WANG Shujuan, MA Lan, XIE Manman, XU Dongpo, LIU Cheng, DING Chengchao, GUO Liang, FANG Shuiqin, WANG Xiang, QIU Jingxuan, DONG Qingli, LIU Qing   

  1. (School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China)
  • Online:2019-09-15 Published:2019-09-23

Abstract: Lateral flow immunoassay (LFIA), which combines the excellent separation ability of chromatography with the high specificity and sensitivity of conventional immunoassays, has served as an ideal platform for quantitative and sensitive on-site detection and played a significant role in food safety detection. The label is one of the key determinants of the sensitivity of LFIA. At present, the detection performance of LFIA is mainly enhanced by using nanoparticles (NPs) as labels including colored, luminescent and magnetic NPs. This paper is aimed to summarize the recent advances in the development of nanoparticle-based lateral flow immunochromatography. The application of various types of nanoparticles to improve the analytical performance is elaborated. This review is expected to provide powerful technical support for the selection of suitable nanoparticles for LFIA.

Key words: nanoparticles, label, lateral flow immunoassay

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