Abstract: In recent years, polysaccharides have been widely used as immunomodulators in the regulation of macrophage surface receptor-mediated immunoregulation. Polysaccharide receptors on the surface of macrophages have become a research hotspot. Macrophages belong to immune cells and participate in mediating inflammation, repairing tissue damage, and recognizing and phagocytizing pathogens. The phagocytosis of macrophages begins with the recognition of endocytosis, which is closely related to macrophage surface receptors. Studies have shown that polysaccharides can promote macrophage phagocytosis, but the underlying mechanism is yet unclear. In this review, we explore the relationship between polysaccharide receptors on the macrophage surface and macrophage phagocytosis, which will provide useful information for future studies of polysaccharide-activated cell phagocytosis.

Key words: polysaccharide, immunity, polysaccharide receptor, macrophage, phagocytosis