Effects of Different Protein Intakes on Adiponectin Signaling Pathway in Liver of Rats with Energy Limited and yperacute

Abstract

Abstract: Abstract: Objective To study the effect of different protein intake on adiponectin signaling pathway in the liver of SD overweight male rats. Method 36 male SD rats were randomly divided into three groups: normal control group (NC) and model making group (30 rats). After 9 weeks, the rats were randomly divided into model control group (MC), low energy and low protein group (LP), low energy and normal protein group (NP), low energy and high protein group (HP) for energy and protein control. After 9 weeks, the weight, body fat and liver weight of rats in each group were measured , liver fat, adiponectin (APN), amp activated protein kinase (AMPK), sterol regulatory element binding protein 1c (SREBP-1c), acety1 CoA carboxylase (ACC), fatty acid synthetase（FAS）,peroxisome proliferators activated receptors (PPAR α), carnitine palmitoyl transferase-1 (CPT-1) contents. Result After 9 weeks of intervention, compared with the MC group, the weight, body fat, liver weight, liver fat, SREBP-1c, ACC, FAS content in the liver of the intervention group were significantly reduced (P < 0.05), while the adiponectin content, AMPK, PPAR α, CPT1 content in the liver were significantly increased (P < 0.05). There was no significant difference between the three intervention groups in weight, body fat, liver weight, CPT1, AMPK, FAS content in the liver (P > 0.05) Compared with NP group, the liver fat quality of HP group decreased significantly, and the contents of APN, SREBP-1c, ACC and PPARα increased significantly (P < 0.05). Conclusion After energy control, the content of each factor in the "APN-AMPK" and "APN-PPARα-CPT1" signal pathways in the liver of overweight male rats increased significantly, which reduced the weight, liver weight and liver fat mass of overweight male rats to a certain extent; under the same energy limit, high protein intake can promote the activation of APN-PPARα signal pathway, thus reducing the liver fat mass of overweight male rats, But it has no significant effect on body weight, body fat and liver weight.

Key words: Keywords: adiponectin signaling pathway, protein intake, energy limitation

CLC Number:

R33
TS201.3

Zhi-Yan HE YING TIAN. Effects of Different Protein Intakes on Adiponectin Signaling Pathway in Liver of Rats with Energy Limited and yperacute[J]. FOOD SCIENCE, 0, (): 0-0.

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