%0 Journal Article %A YANG Ping %A LI Run-guo %A MENG Xian-jun %T Food Safety and Toxicological Assessment of Eleutheroside %D 2013 %R 10.7506/spkx1002-6630-201311056 %J FOOD SCIENCE %P 258-262 %V 34 %N 11 %X

Objective: To evaluate the safety of eleutheroside, and to provide scientific support for the reasonable utilization
and development of eleutheroside. Methods: According to the national standard procedures and methods in food safety and
toxicological evaluation, a series of toxicological studies on the ingestion of eleutheroside were conducted, which included
acute toxicity, genetic toxicity and subacute toxicity tests. Results: For acute toxicity, the maximum tolerated dose (MTD)
was higher than 20 g/kg. The results of Ames test, mouse bone marrow micronucleus test and mouse sperm abnormality
test were negative. After 30 d of feeding, rats showed no significant difference in body growth, organ development or
histological observation. Conclusion: Eleutheroside is actually non-toxic with no genetic toxicity. No adverse effect of
eleutheroside at 20 g/kg has been observed during trails for 30 d.

%U https://www.spkx.net.cn/EN/10.7506/spkx1002-6630-201311056