[1]张泽生, 卢亚莉, 高云峰, 等. 菊苣中苦味物质的研究进展[J]. 中国食品添加剂, 2015, 5: 174-178. DOI: 10.3969/j.issn.1006-2513.2015.05.021.[2]刘宗昭, 卢丕超, 王晓军, 等. 葡萄酒产生苦味的影响因素[J]. 酿酒科技, 2020, (12): 54-59. DOI: 10.13746/j.njkj.2020133.[3]王琳涵, 乔凯娜, 丁奇, 等. 不同煮制时间对鸡汤中呈味物质的影响[J]. 精细化工, 2018, 35(10): 1683-1690. DOI: 10.13550/j.jxhg.20170704.[4]TOELSTEDE S, DUNKEL A, HOFMANN T. A series of kokumi peptides impart the long-lasting mouthfulness of matured gouda cheese[J]. Journal of Agricultural and Food Chemistry, 2009, 57(4): 1440–1448. DOI: 10.1021/jf803376d.[5]STARK T, HOFMANN T. Structures, sensory activity, and dose/response functions of 2,5-diketopiperazines in roasted cocoa nibs (Theobroma cacao)[J]. Journal of Agricultural and Food Chemistry, 2005, 53(18): 7222-7231. DOI: 10.1021/jf051313m.[6]DAGAN-WIENER A , PIZIO A D, NISSIM I, et al. BitterDB: taste ligands and receptors database in 2019[J]. Nuclc Acids Research, 2019, 47(1): 1179-1185. DOI: 10.1093/nar/gky974.[7]GLENDINNING J I. Is the bitter rejection response always adaptive?[J]. Physiology and Behavior, 1994, 56(6): 1217-1227. DOI: 10.1016/0031-9384(94)90369-7.[8]GUINARD J X, HONG D Y, ZOUMAS-MORSE C, et al. Chemoreception and perception of the bitterness of isohumulones[J]. Physiology and Behavior, 1994, 56(6): 1257-1263. DOI: 10.1016/0031-9384(94)90374-3.[9]BELITZ H, WIESER H. Bitter compounds: Occurrence and structure-activity relationships[J]. Food Reviews International, 1985, 1(2): 271-354. DOI: 10.1080/87559128509540773.[10]INTELMANN D, BATRAM C, KUHN C, et al. Three TAS2R bitter taste receptors mediate the psychophysical responses to bitter compounds of hops (Humulus lupulus L.) and beer[J]. Chemosensory Perception, 2009, 2(3): 118-132. DOI: 10.1007/s12078-009-9049-1.[11]TORDOFF M G. Some basic psychophysics of calcium salt solutions[J]. Chemical Senses, 1996(4):417-424. DOI: 10.1093/chemse/21.4.417.[12]NISHIMURA T, KATO H.?Taste of free amino acids and peptides[J]. Food Reviews International, 1988, 4(2): 175-194.?DOI: 10.1080/87559128809540828.[13]张恒. 鸡骨酶解过程中的呈味特性及氨基酸释放规律研究[D]. 雅安: 四川农业大学, 2010: 1-5.[14]丁奇, 赵静, 孙颖, 等. 4种鸡汤中游离氨基酸的组成及呈味贡献对比分析[J]. 精细化工, 2015, 32(11): 1260-1265. DOI: 10.13550/j.jxhg.2015.11.011.[15]许永红. 蛋白质酶法水解物苦味的控制[J]. 食品工业科技, 1997(3). DOI: CNKI:SUN:SPKJ.0.1997-03-000.[16]魏沙沙, 彭静, 陈志丹, 等. 尤溪苦茶苦味相关物质检测及与苦味的关联分析[J]. 茶叶科学, 2021, 41(3): 337-349. DOI: 10.13305/j.cnki.jts.2021.03.003.[17]NEY H K. Bitterness of peptides: amino acid composition and chain length[J]. Acs Symposium Series, 1979, 115: 149-173.?DOI: 10.1021/bk-1979-0115.ch006.?[18]田霄艳, 郑斐庭, 冯涛, 等. 大豆蛋白水解物苦味评价方法研究[J]. 食品科学,2022, 43(3): 25-32. DOI: 10.7506/spkx1002-6630-20210309-120.[19]TOELSTEDE S,?HOFMANN T.?Sensomics mapping and identification of the key bitter metabolites in gouda cheese[J]. Journal of Agricultural and Food Chemistry,?2008, 56(8): 2795-2804. DOI: 10.1021/jf7036533.[20]MAEHASHI K, HUANG L. Bitter peptides and bitter taste receptors[J]. Cellular and Molecular Life Sciences, 2009, 66(10): 1661-1671. DOI: 10.1007/s00018-009-8755-9.[21]李姝琪, 郭晓梦, 张惠玲. 不同发酵条件对欧李酒多酚含量及苦味的影响[J]. 食品工业, 2021, 42(12): 6-10.[22]THORNGATEIII J H, NOBLE A C. Sensory evaluation of bitterness and astringency of 3 R(-) - epicatechin and 3 S(+) - catechin[J]. Journal of the Science of Food and Agriculture, 2010, 67(4): 531-535. DOI: 10.1002/jsfa.2740670416.[23]李明超, 刘莹, 杨洋, 等. 紫娟茶主要化学成分及药理活性研究进展[J]. 食品安全质量检测学报, 2019(8): 2293-2299. DOI: 10.3969/j.issn.2095-0381.2019.08.032.[24]郝晓霞. 苦味物质研究概况[J]. 黄冈师范学院学报, 2008, 28(6): 90-92. DOI: 10.3969/j.issn.1003-8078.2008.z1.041.[25]金日生. 生物碱类化合物配位色谱分析方法研究[D]. 合肥: 合肥工业大学, 2009.[26]代丽凤, 罗理勇, 罗江琼, 等. 植物苦味物质概况及其在食品工业的应用[J]. 中国食品学报, 2020, 20(11): 305-318. DOI: 10.16429/j.1009-7848.2020.11.035.[27]KLAAUW N, SMITH D V. Taste quality profiles for fifteen organic and inorganic salts[J]. Physiology and Behavior, 1995, 58(2): 295-306. DOI: info:doi/10.1016/0031-9384(95)00056-O.[28]蔡丽华, 马美湖. 骨蛋白酶解及风味肽分离现代技术研究进展[J]. 肉类研究, 2008, (6): 57-61. DOI: 10.3969/j.issn.1001-8123.2008.06.014.[29] ZHU X P, SUN-WATERHOUSE D X, CHEN J H, et al. Bitter-asting hydrophobic peptides prepared from soy sauce using aqueous ethanol solutions influence taste sensation[J]. International Journal of Food Science and Technology, 2020, 55(1): 146-156. DOI: 10.1111/ijfs.14271.[30]HUFNAGEL J C, HOFMANN T. Quantitative reconstruction of the nonvolatile sensometabolome of a red wine[J]. Journal of Agriculture and Food Chemistry, 2008, 56(19): 9190-9199. DOI: 10.1021/jf801742w.[31]CZEPA A, HOFMANN T. Structural and sensory characterization of compounds contributing to the bitter off-taste of carrots (Daucus carota L.) and carrot puree[J]. Journal of Agriculture and Food Chemistry, 2003, 51(12): 3865-3873. DOI: 10.1021/jf034085+.[32]赵腾飞. 基于感官导向的酱香型白酒后鼻嗅糊香和难挥发性苦味物质解析[D]. 无锡, 江南大学, 2019: 20-23.[33]皇甫文倩, 金文苑, 胡新中. 燕麦加工中苦味物质的分离与初步鉴定[J]. 食品安全质量检测学报, 2019, 10(15): 4890-4895. DOI: CNKI:SUN:SPAJ.0.2019-15-013.[34]QIAN D, CHEN J, LAI C, et al. Dicaffeoyl polyamine derivatives from bitter goji: contribution to the bitter taste of wolfberry[J]. Fitoterapia, 2020, 143:104543. DOI: 10.1016/j.fitote.2020.104543.[35]GAO Q, JIANG H, TANG F, et al. Evaluation of the bitter components of bamboo shoots using a metabolomics approach[J]. Food and Function, 2018, 10(1): 90-98. DOI: 10.1039/C8FO01820K.[36]MINKIEWICZ P, IWANIAK A, DAREWICZ M. BIOPEP-UWM database of bioactive peptides: current opportunities[J]. International Journal of Molecular Sciences, 2019, 20(23): 5978. DOI:10.3390/ijms20235978.[37]HUANG W, SHEN Q, SU X, et al. BitterX: a tool for understanding bitter taste in humans[J]. Scientific Reports, 2016, 6(1):23450. DOI: 10.1038/srep23450.[38] CHAROENKWANA P, YANA J, SCHADUANGRAT N, et al. iBitter-SCM: Identification and characterization of bitter peptides using a scoring card method with propensity scores of dipeptides[J]. Genomics, 2020, 112(4): 2813-2822. DOI: 10.1016/j.ygeno.2020.03.019.[39]CHAROENKWAN P, NANTASENAMAT C, HASAN M M, et al. iBitter-Fuse: A Novel Sequence-Based Bitter Peptide Predictor by Fusing Multi-View Features[J].?International Journal of Molecular Sciences, 2021, 22(16): 8958.?DOI: 10.3390/ijms22168958.[40]NTIE-KANG F. Mechanistic role of plant-based bitter principles and bitterness prediction for natural product studies II: prediction tools and case studies[J]. 2019. DOI: 10.1515/psr-2019-010z.[41]ZHANG L L, ZHAO L, WANG H Y, et al. Determination of Recognition Threshold and Just Noticeable Difference in the Sensory Perception of Pungency of Zanthoxylum bangeanum[J]. International Journal of Food Properties, 2016, 19(5):1044-1052. DOI: 10.10.80/10942912.2015.1054037.[42]FRANK O, OTTINGER H, HOFMANN T. Characterization of an intense bitter-tasting 1H,4H-quinolizinium-7-olate by application of the taste dilution analysis, a novel bioassay for the screening and identification of taste-active compounds in foods[J]. Journal of Agricultural and Food Chemistry, 2001, 49(1): 231-238. DOI: 10.1021/jf0010073.[43]陈兆斌. 氨基酸的苦味淬灭研究及评价模型的构建[D]. 南京: 南京大学, 2013.[44]QIN Z, ZHANG B, HU L, et al. A novel bioelectronic tongue in vivo for highly sensitive bitterness detection with brain-machine interface[J]. Biosensors and Bioelectronics, 2015, 78: 374-380.?DOI: 10.1016/j.bios.2015.11.078.[45]BRASSER S M, MOZHUI K, SMITH D V. Differential covariation in taste responsiveness to bitter stimuli in rats[J]. Chemical Senses, 2005, 30(9): 793-799. DOI: 10.1093/chemse/bji071.[46]刘斯斯. 咖啡因苦味适应小鼠模型的建立及其外周机制初步研究[D]. 苏州: 苏州大学, 2012. [47]梁晓光, 吴飞, 王优杰,等. 基于现代电子舌技术的传统苦味中药黄连的苦味物质基础研究[J]. 中国中药杂志, 2014, 39(17): 3326-3329. DOI: 10.4268/cjcmm20141723.[48]吴颖. 离子交换树脂用于黄连掩味研究及其电子舌评价方法的建立[D]. 上海: 上海中医药大学, 2011.[49]胡玲玲, 施鹏. 苦味受体基因家族功能和演化研究的最新进展[J]. 科学通报, 2009, (17): 2472-2482. DOI: 10.1360/972009-1142.[50]KUHN C. Bitter taste receptors for saccharin and acesulfame K[J]. Journal of Neuroscience, 2004, 24(45): 10260-10265. DOI: 10.1523/JNEUROSCI.1225-04.2004.[51]胡靓. 苦味细胞传感技术及其在苦味转导机理中的应用[D]. 杭州: 浙江大学, 2016.[52]焦丽华. 基于老鼠味蕾辣味生物传感器的开发研究[D]. 天津: 天津商业大学, 2014.[53]LIU Q, ZHANG D, ZHANG F, et al. Biosensor recording of extracellular potentials in the taste epithelium for bitter detection[J]. Sensors and Actuators B: Chemical, 2013, 176: 497-504. DOI: 10.1016/j.snb.2012.08.074.[54]BEHRENS M, MEYERHOF W. Gustatory and extragustatory functions of mammalian taste receptors[J]. Physiology & Behavior, 2011, 105(1): 4-13. DOI: 10.1016/j.physbeh.2011.02.010.[55]REICHLING C, MEYERHOF W, BEHRENS M. Functions of human bitter taste receptors depend on N-glycosylation[J]. Journal of Neurochemistry, 2010, 106(3): 1138-1148. DOI: 10.1111/j.1471-4159.2008.05453.x.[56]ROPER S D, CHAUDHARI N. Taste buds: cells, signals and synapses[J]. Nature Reviews Neuroscience, 2017, 18(8): 485-97. DOI: 10.1038/nrn.2017.68.[57]曹英东, 李方方, 张勇, 等. 苦味受体的生物学特征,信号转导机制及苦味剂和苦味抑制剂对苦味受体的影响[J]. 动物营养学报, 2017, 29(3): 769-775. DOI: CNKI:SUN:DWYX.0.2017-03-006.[58]MARGOLSKEE R F. Molecular Mechanisms of Bitter and Sweet Taste Transduction[J]. Journal of Biological Chemistry, 2002, 277(1): 1-4. DOI: 10.1074/jbc.R100054200.[59]PRONIN A N, TANG H, CONNOR J, et al. Identification of ligands for two human bitter T2R receptors[J]. Chemical Senses, 2004, 29(7): 583-593. DOI: 10.1093/chemse/bjh064.[60]ADLER E, HOON M A, Mueller K L, et al. A novel family of mammalian taste receptors[J]. Cell, 2000, 100(6): 693-702. DOI: 10.1016/S0092-8674(00)80705-9.[61]ZHANG Y, HOON M A, CHANDRASHEKAR J, et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways[J]. Cell, 2003, 112(3): 293-301. DOI: 10.1016/S0092-8674(03)00071-0.[62]LIU K, JAGGUPILLI A, PREMNATH D, et al. Plasticity of the ligand binding pocket in the bitter taste receptor T2R7[J]. Biochimica et Biophysica Acta Biomembranes, 2018, 1860(5): 991-999. DOI: 10.1016/j.bbamem.2018.01.014.[63]PYDI S P, SINGH N, UPADHYAYA J, et al. The third intracellular loop plays a critical role in bitter taste receptor activation[J]. Biochimica et Biophysica Acta - Biomembranes, 2014, 1838(1): 231-236. DOI:10.1016/j.bbamem.2013.08.009.[64]DAI W M, YOU Z L, ZHOU H, et al. Structure–function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies[J]. Journal of Receptors & Signal Transduction, 2011, 31(3): 229-240. DOI: 10.3109/10799893.2011.578141.[65]BORN S, LEVIT A, NIV M Y, et al. The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands[J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2013, 33(1): 201-13. DOI: 10.1523/JNEUROSCI.3248-12.2013.[66]ALLEN A L, MCGEARY J E,?KNOPIK V S, et al. Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31[J]. Chemical Senses, 2013, 38(5):379-389. DOI: 10.1093/chemse/bjt017.[67]BORNEMAN Z, G?KMEN V, NIJHUIS H H.?Selective removal of polyphenols and brown colour in apple juices using PES/PVP membranes in a single-ultrafiltration process[J]. Journal of Membrane Science, 1997, 134(2): 191-197.?DOI: 10.1016/s0376-7388(97)00105-1.?[68]LEY J P.?Masking bitter taste by molecules[J]. Chemosensory Perception, 2008, 1(1): 58-77.?DOI: 10.1007/s12078-008-9008-2.?[69]IMAI K, IKEDA A, SHIMIZU K, et al. Selective Elimination of Bitter Peptides by Adsorption to Heat-treated Porous Silica Gel[J]. Food Science and Technology Research, 2019, 25(2): 179-186. DOI: 10.3136/fstr.25.179.[70]YILMAZ E, DEVIREN A. Silica gel 60 removes bitterness from cold-press produced grapefruit seed oil by adsorption principle[J]. Flavour and Fragrance Journal, 2022, 37(1): 52-62. DOI: 10.1002/ffj.3683.[71]YE F, YANG R, HUA X, et al. Modification of stevioside using transglucosylation activity of bacillus amyloliquefaciens α-amylase to reduce its bitter aftertaste[J]. LWT - Food Science and Technology, 2013, 51(2): 524-530. DOI: 10.1016/j.lwt.2012.12.005.[72]NEWMAN J, O'RIORDAN D, JACQUIER J C, et al. Masking of bitterness in dairy protein hydrolysates: comparison of an electronic tongue and a trained sensory panel as means of directing the masking strategy.[J]. LWT - Food Science and Technology, 2015, 63(1): 751-757. DOI: 10.1016/j.lwt.2015.03.019.[73]SAKURAI T, MISAKA T, NAGAI T et al. pH-Dependent inhibition of the human bitter taste receptor hTAS2R16 by a variety of acidic substances[J]. Journal of Agricultural and Food Chemistry, 2009, 57(6), 2508-2514.?DOI: 10.1021/jf8040148.[74]KIM M J, SON H J, KIM Y, et al.?Umami-bitter interactions: The suppression of bitterness by umami peptides via human bitter taste receptor[J]. Biochemical and Biophysical Research Communications, 2015, 456(2): 586-590.?DOI: 10.1016/j.bbrc.2014.11.114.?[75]RHYU M R, KIM Y, MISAKA T.?Suppression of hTAS2R16 signaling by umami substances[J]. International Journal of Molecular Sciences, 2020, 21(19): 7045.?DOI: 10.3390/ijms21197045.[76]WANG W L, ZHOU X R, LIU Y.?Characterization and evaluation of umami taste: A review[J]. TrAC Trends in Analytical Chemistry, 2020, 127: 115876.?DOI: 10.1016/j.trac.2020.115876?.[77]SUN-WATERHOUSE D, WADHWA S S.?Industry-relevant approaches for minimising the bitterness of bioactive compounds in functional foods: A review[J]. Food and Bioprocess Technology, 2013, 6(3), 607-627.?DOI: 10.1007/s11947-012-0829-2.?[78]SUESS B, BROCKHOFF A, MEYERHOF W, et al. The odorant (r)-citronellal attenuates caffeine bitterness by inhibiting the bitter receptors TAS2R43 and TAS2R46[J]. Journal of Agricultural and Food Chemistry, 2016, 66(10): 2301-2311. DOI:10.1021/acs.jafc.6b03554.[79]ONO N, MIYAMOTO Y, ISHIGURO T, et al. Reduction of Bitterness of Antihistaminic Drugs by Complexation with?β-Cyclodextrins[J]. Journal of Pharmaceutical Sciences, 2011, 100(5): 1935-1943. DOI: 10.1002/jps.22417.[80]BINELLO A, CRAVOTTO G, NANO G M,et al. Synthesis fo chitosan-cyclodextrin adducts and evaluation of their bitter-masking properties. Flavour and Fragrance Journal, 2004, 19(5): 394-400. DOI: 10.1002/ffj.1434.[81]SONODA C, SAKAI K, MURASE K. Bitterness relieving agent[M]. WO2000021390 A1, 2000.[82]HAYASHI N, UJIHARA T, KOHATA K. Reduction of Catechin Astringency by the complexation of gallate-type catechins with pectin[J]. Bioscience, Biotechnology and Biochemistry, 2014, 69(7): 1306-1310. DOI: 10.1271/bbb.69.1306.[83]SANDELL M, HOPPU U, LUNDéNA S, et al. Consumption of lingonberries by TAS2R38 genotype and sensory quality of texture-designed lingonberry samples[J]. Food Quality and Preference, 2015, 45: 166-170. DOI: 10.1016/j.foodqual.2015.06.015.[84]ZHOU C Y, WANG C, CAI J H, et al. Evaluating the effect of protein modifications and water distribution on bitterness and adhesiveness of Jinhua ham[J]. Food Chemistry, 2019, 293: 103-111. DOI: 10.1016/j.foodchem.2019.04.095. |