响应面试验优化复凝聚法制备槲皮素微胶囊工艺及其理化性质

doi:10.7506/spkx1002-6630-201622004

食品科学 ›› 2016, Vol. 37 ›› Issue (22): 20-27.doi: 10.7506/spkx1002-6630-201622004

响应面试验优化复凝聚法制备槲皮素微胶囊工艺及其理化性质

廖霞¹，杨小兰¹，李瑶¹，王丽颖¹，明建¹,²,*

1.西南大学食品科学学院，重庆 400715；
2.重庆市特色食品工程技术研究中心，重庆 400715

收稿日期:2016-04-06 出版日期:2016-11-16 发布日期:2017-02-22
通讯作者: 明建（1972—），男，教授，博士，研究方向为食品化学与营养学。E-mail：mingjian1972@163.com
作者简介:廖霞（1992—），女，硕士研究生，研究方向为食品化学与营养学。E-mail：994671521@qq.com
基金资助:
国家自然科学基金面上项目（31471576）；重庆市社会民生科技创新专项（cstc2015shmszx80019）

Response Surface Optimization of Preparation of Microencapsulated Quercetin Using Complex Coacervation and Its Physicochemical Properties

LIAO Xia¹, YANG Xiaolan¹, LI Yao¹, WANG Liying¹, MING Jian¹,²,*

1. College of Food Science, Southwest University, Chongqing 400715, China；
2. Chongqing Special Food Programme and Technology Research Center, Chongqing 400715, China

Received:2016-04-06 Online:2016-11-16 Published:2017-02-22

摘要/Abstract

摘要： 以槲皮素为芯材，壳聚糖、海藻酸钠为壁材，采用复凝聚法制备槲皮素微胶囊。以包埋率和载药量为综合评价指标，通过单因素试验和响应面试验分析各因素，并对槲皮素微胶囊的理化性质进行研究。结果表明：壁材比（壳聚糖-海藻酸钠质量比）1∶3.34（g/g）、芯壁比4.34∶1（g/g）、京尼平用量18.44 g/100 g壳聚糖、固化温度41.56 ℃时，包埋率为69.53%。制备的槲皮素微胶囊水分含量为3.26%，休止角为40.39°，溶解度为256.44 μg/mL，粒径大小较为均匀，平均粒径为1 362 nm，具有较好的溶解性和稳定性。

关键词: 槲皮素, 复凝聚法, 微胶囊, 理化性质

Abstract: Quercetin microcapsules were prepared by complex coacervation using sodium alginate and chitosan as the wall materials and quercetin as the core material. Single factor experiments and response surface methodology were employed to optimize the preparation conditions based on embedding rate and drug loading. The physicochemical properties of quercetin microcapsules were investigated as well. Under the optimized conditions: sodium alginate/chitosan ratio, 3.34:1; core/wall material ratio, 4.34:1; genipin concentration, 18.44 g/100 g chitosan; and curing temperature, 41.56 ℃, the embedding rate could reach 69.53%. The moisture content, repose angle and solubility of the quercetin microcapsules was 3.26%, 40.39° and 256.44 μg/mL, respectively. The encapsulated quercetin had good solubility and stability.

Key words: quercetin, complex coacervation, microencapsulation, physicochemical properties

中图分类号:

R151.2

廖霞,杨小兰,李瑶,王丽颖,明建,*. 响应面试验优化复凝聚法制备槲皮素微胶囊工艺及其理化性质[J]. 食品科学, 2016, 37(22): 20-27.

LIAO Xia, YANG Xiaolan, LI Yao, WANG Liying, MING Jian,*. Response Surface Optimization of Preparation of Microencapsulated Quercetin Using Complex Coacervation and Its Physicochemical Properties[J]. FOOD SCIENCE, 2016, 37(22): 20-27.

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响应面试验优化复凝聚法制备槲皮素微胶囊工艺及其理化性质

Response Surface Optimization of Preparation of Microencapsulated Quercetin Using Complex Coacervation and Its Physicochemical Properties

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